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Rabbit Anti-RAP1B Recombinant Antibody (360) (CBMAB-R1313-CN)

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Basic Information

Host Animal
Rabbit
Clone
360
Application
WB
Specificity
Human, Mouse, Rat, Monkey, Cattle, Pig
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
More Infomation

Target

Full Name
RAP1B, Member Of RAS Oncogene Family
Introduction
This gene encodes a member of the RAS-like small GTP-binding protein superfamily. Members of this family regulate multiple cellular processes including cell adhesion and growth and differentiation. This protein localizes to cellular membranes and has been shown to regulate integrin-mediated cell signaling. This protein also plays a role in regulating outside-in signaling in platelets. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 3, 5, 6 and 9. [provided by RefSeq, Oct 2011]
Entrez Gene ID
Human5908
Mouse215449
Rat171337
Monkey718171
Cattle327708
Pig100152555
UniProt ID
HumanP61224
MouseQ99JI6
RatQ62636
MonkeyA0A1D5QWX3
CattleP61223
PigA0A286ZVJ2
Alternative Names
RAP1B, Member Of RAS Oncogene Family; GTP-Binding Protein Smg P21B; Ras Family Small GTP Binding Protein RAP1B; Ras-Related Protein Rap-1b; RAS-Related Protein RAP1B; Small GTP Binding Protein; K-Rev; RAL1B;
Function
GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction. Plays a role in the establishment of basal endothelial barrier function.
Biological Process
Biological Process calcium-ion regulated exocytosisIEA:Ensembl
Biological Process cell population proliferationIEA:Ensembl
Biological Process cellular response to cAMPManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process establishment of endothelial barrierManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process establishment of localization in cellIEA:Ensembl
Biological Process negative regulation of calcium ion-dependent exocytosisIEA:Ensembl
Biological Process negative regulation of synaptic vesicle exocytosisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of ERK1 and ERK2 cascadeIEA:Ensembl
Biological Process positive regulation of integrin activationManual Assertion Based On ExperimentIMP:ARUK-UCL
Biological Process Rap protein signal transductionManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of cell junction assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of establishment of cell polarityManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Cell membrane
Cytoplasm, cytosol
Cell junction
May shuttle between plasma membrane and cytosol (PubMed:3141412).
Presence of KRIT1 and CDH5 is required for its localization to the cell junction (PubMed:20332120).
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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

Rabbit Anti-RAP1B Recombinant Antibody (36E1) (CAT#: CBMAB-CP2209-LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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