RAP1B

This gene encodes a member of the RAS-like small GTP-binding protein superfamily. Members of this family regulate multiple cellular processes including cell adhesion and growth and differentiation. This protein localizes to cellular membranes and has been shown to regulate integrin-mediated cell signaling. This protein also plays a role in regulating outside-in signaling in platelets. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 3, 5, 6 and 9. [provided by RefSeq, Oct 2011]

Full Name

RAP1B, Member Of RAS Oncogene Family

Function

GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction. Plays a role in the establishment of basal endothelial barrier function.

Biological Process

Biological Process calcium-ion regulated exocytosisIEA:Ensembl
Biological Process cell population proliferationIEA:Ensembl
Biological Process cellular response to cAMPManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process establishment of endothelial barrierManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process establishment of localization in cellIEA:Ensembl
Biological Process negative regulation of calcium ion-dependent exocytosisIEA:Ensembl
Biological Process negative regulation of synaptic vesicle exocytosisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of ERK1 and ERK2 cascadeIEA:Ensembl
Biological Process positive regulation of integrin activationManual Assertion Based On ExperimentIMP:ARUK-UCL
Biological Process Rap protein signal transductionManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of cell junction assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of establishment of cell polarityManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Cell membrane
Cytoplasm, cytosol
Cell junction
May shuttle between plasma membrane and cytosol (PubMed:3141412).
Presence of KRIT1 and CDH5 is required for its localization to the cell junction (PubMed:20332120).