Mouse Anti-RBBP5 Recombinant Antibody (1C9) (CBMAB-R1643-CN)

Name: Mouse Anti-RBBP5 Recombinant Antibody (1C9)
SKU: CBMAB-R1643-CN
Rating: 5 (1 reviews)

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Datasheet

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Basic Information

Host Animal

Mouse

Clone

1C9

Application

IF, WB

Immunogen

Recombinant protein corresponding to human RBBP5 expressed in E. coli

Specificity

Human, Mouse, Rat

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

0.1M Tris-Glycine, pH 7.4, 0.15M NaCl, 50% Glycerol

Preservative

0.2% sodium azide

More Infomation

Target

Full Name

RBBP5

Introduction

This gene encodes a ubiquitously expressed nuclear protein which belongs to a highly conserved subfamily of WD-repeat proteins. The encoded protein binds directly to retinoblastoma protein, which regulates cell proliferation. It interacts preferentially with the underphosphorylated retinoblastoma protein via the E1A-binding pocket B. Three alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2010]

Entrez Gene ID

Human	5929
Mouse	213464
Rat	304794

UniProt ID

Human	Q15291
Mouse	Q8BX09
Rat	D3ZC01

Alternative Names

RB Binding Protein 5, Histone Lysine Methyltransferase Complex Subunit; Retinoblastoma-Binding Protein RBQ-3; Retinoblastoma-Binding Protein 5; RBBP-5; RBQ3; SWD1, Set1c WD40 Repeat Protein, Homolog (S. Cerevisiae); SWD1, Set1c WD40 Repeat Protein, Homolog; Retinoblastoma Binding Protein 5; SWD1;

Function

In embryonic stem (ES) cells, plays a crucial role in the differentiation potential, particularly along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci, including that mediated by retinoic acid (By similarity).
Does not affect ES cell self-renewal (By similarity).
Component or associated component of some histone methyltransferase complexes which regulates transcription through recruitment of those complexes to gene promoters (PubMed:19131338).
As part of the MLL1/MLL complex, involved in mono-, di- and trimethylation at 'Lys-4' of histone H3 (PubMed:19556245).
Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation (PubMed:19556245).
In association with ASH2L and WDR5, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B (PubMed:22266653, PubMed:21220120).

Biological Process

Biological Process cellular response to DNA damage stimulusManual Assertion Based On ExperimentIDA:MGI
Biological Process chromatin organizationIEA:UniProtKB-KW
Biological Process histone H3-K4 methylationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process response to estrogenManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Nucleus

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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