RBBP5

This gene encodes a ubiquitously expressed nuclear protein which belongs to a highly conserved subfamily of WD-repeat proteins. The encoded protein binds directly to retinoblastoma protein, which regulates cell proliferation. It interacts preferentially with the underphosphorylated retinoblastoma protein via the E1A-binding pocket B. Three alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2010]
Full Name
RBBP5
Function
In embryonic stem (ES) cells, plays a crucial role in the differentiation potential, particularly along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci, including that mediated by retinoic acid (By similarity).
Does not affect ES cell self-renewal (By similarity).
Component or associated component of some histone methyltransferase complexes which regulates transcription through recruitment of those complexes to gene promoters (PubMed:19131338).
As part of the MLL1/MLL complex, involved in mono-, di- and trimethylation at 'Lys-4' of histone H3 (PubMed:19556245).
Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation (PubMed:19556245).
In association with ASH2L and WDR5, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B (PubMed:22266653, PubMed:21220120).
Biological Process
Biological Process cellular response to DNA damage stimulusManual Assertion Based On ExperimentIDA:MGI
Biological Process chromatin organizationIEA:UniProtKB-KW
Biological Process histone H3-K4 methylationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process response to estrogenManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Nucleus
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Anti-RBBP5 antibodies

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Mouse Anti-RBBP5 Recombinant Antibody (1C9-1C9-H10) (CBMAB-Z0365-LY)

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Target: RBBP5
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse, Rat
Clone: 1C9-1C9-H10
Application*: WB, IF
Datasheet SDS

Mouse Anti-RBBP5 Recombinant Antibody (R567.1.1C3) (CBMAB-R1646-CN)

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Target: RBBP5
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: R567.1.1C3
Application*: IP
Datasheet SDS

Rabbit Anti-RBBP5 Recombinant Antibody (D4Y7R) (CBMAB-R1645-CN)

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Target: RBBP5
Host: Rabbit
Specificity: Human, Mouse, Rat, Monkey, Chicken, Frog, Zebrafish
Clone: D4Y7R
Application*: WB
Datasheet SDS

Rabbit Anti-RBBP5 Recombinant Antibody (D3I6P) (CBMAB-R1644-CN)

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Target: RBBP5
Host: Rabbit
Specificity: Human, Mouse, Rat, Monkey, Chicken, Frog, Cattle
Clone: D3I6P
Application*: WB, IP, CI
Datasheet SDS

Mouse Anti-RBBP5 Recombinant Antibody (1C9) (CBMAB-R1643-CN)

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Target: RBBP5
Host: Mouse
Specificity: Human, Mouse, Rat
Clone: 1C9
Application*: IF, WB
Datasheet SDS

Mouse Anti-RBBP5 Monoclonal Antibody (1C3) (CBMAB-0028-LY)

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Target: RBBP5
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 1C3
Application*: IP, M
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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