Sign in or Register   Sign in or Register
  |  

Rabbit Anti-RBBP5 Recombinant Antibody (D3I6P) (CBMAB-R1644-CN)

This product is a Rabbit antibody that recognizes RBBP5. The antibody D3I6P can be used for immunoassay techniques such as: WB, IP, ChIP.
See all RBBP5 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat, Monkey, Chicken, Frog, Cattle
Clone
D3I6P
Application
WB, IP, ChIP

Basic Information

Specificity
Human, Mouse, Rat, Monkey, Chicken, Frog, Cattle
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Target

Full Name
RBBP5
Introduction
This gene encodes a ubiquitously expressed nuclear protein which belongs to a highly conserved subfamily of WD-repeat proteins. The encoded protein binds directly to retinoblastoma protein, which regulates cell proliferation. It interacts preferentially with the underphosphorylated retinoblastoma protein via the E1A-binding pocket B. Three alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2010]
Entrez Gene ID
Human5929
Mouse213464
Rat304794
Monkey699057
Frog595072
Chicken419826
Cattle510455
UniProt ID
HumanQ15291
MouseQ8BX09
RatD3ZC01
MonkeyH9ENY9
ChickenQ5ZLX3
FrogF6QZB2
CattleA4FUE3
Alternative Names
RB Binding Protein 5, Histone Lysine Methyltransferase Complex Subunit; Retinoblastoma-Binding Protein RBQ-3; Retinoblastoma-Binding Protein 5; RBBP-5; RBQ3; SWD1, Set1c WD40 Repeat Protein, Homolog (S. Cerevisiae); SWD1, Set1c WD40 Repeat Protein, Homolog; Retinoblastoma Binding Protein 5; SWD1;
Function
In embryonic stem (ES) cells, plays a crucial role in the differentiation potential, particularly along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci, including that mediated by retinoic acid (By similarity).
Does not affect ES cell self-renewal (By similarity).
Component or associated component of some histone methyltransferase complexes which regulates transcription through recruitment of those complexes to gene promoters (PubMed:19131338).
As part of the MLL1/MLL complex, involved in mono-, di- and trimethylation at 'Lys-4' of histone H3 (PubMed:19556245).
Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation (PubMed:19556245).
In association with ASH2L and WDR5, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B (PubMed:22266653, PubMed:21220120).
Biological Process
Biological Process cellular response to DNA damage stimulusManual Assertion Based On ExperimentIDA:MGI
Biological Process chromatin organizationIEA:UniProtKB-KW
Biological Process histone H3-K4 methylationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process response to estrogenManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Nucleus
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Rabbit Anti-RBBP5 Recombinant Antibody (D3I6P)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare