Mouse Anti-RBFOX1 Recombinant Antibody (3D12) (CBMAB-R1689-CN)

Name: Mouse Anti-RBFOX1 Recombinant Antibody (3D12)
SKU: CBMAB-R1689-CN
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

3D12

Application

Immunogen

Human recombinant protein fragment corresponding to aa. 1-210 of human RBFOX1 (NP_061193) produced in E.coli

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.3, 1% BSA, 50% Glycerol

Preservative

0.02% Sodium azide

Concentration

1 mg/mL

More Infomation

Target

Full Name

RNA binding protein fox-1 homolog 1

Introduction

The Fox-1 family of RNA-binding proteins is evolutionarily conserved, and regulates tissue-specific alternative splicing in metazoa. Fox-1 recognizes a (U)GCAUG stretch in regulated exons or in flanking introns. The protein binds to the C-terminus of ataxin-2 and may contribute to the restricted pathology of spinocerebellar ataxia type 2 (SCA2). Ataxin-2 is the product of the SCA2 gene which causes familial neurodegenerative diseases. Fox-1 and ataxin-2 are both localized in the trans-Golgi network. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

Entrez Gene ID

54715

UniProt ID

Q9NWB1

Alternative Names

RNA Binding Fox-1 Homolog 1; RNA Binding Protein, Fox-1 Homolog 1; Hexaribonucleotide-Binding Protein 1; Ataxin 2-Binding Protein 1; Fox-1 Homolog A; HRNBP1; A2BP1; FOX1; Hexaribonucleotide Binding Protein 1 Isoform Alpha; RNA Binding Protein, Fox-1 Homolog (C. Elegans) 1;

Function

RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUGU-3' elements. Regulates alternative splicing of tissue-specific exons and of differentially spliced exons during erythropoiesis.

Biological Process

mRNA processing
Nervous system development
Regulation of alternative mRNA splicing, via spliceosome
RNA splicing
RNA transport

Cellular Location

Nucleus; Cytoplasm

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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