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Mouse Anti-RBFOX1 Recombinant Antibody (1F7) (CBMAB-R1685-CN)

This product is a Mouse antibody that recognizes RBFOX1. The antibody 1F7 can be used for immunoassay techniques such as: WB, IHC.
See all RBFOX1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1F7
Antibody Isotype
IgG1
Application
WB, IHC

Basic Information

Immunogen
Human recombinant protein fragment corresponding to aa. 1-210 of human RBFOX1 (NP_061193) produced in E.coli
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.3, 1% BSA, 50% Glycerol
Preservative
0.02% Sodium azide
Concentration
1 mg/mL

Target

Full Name
RNA binding protein fox-1 homolog 1
Introduction
The Fox-1 family of RNA-binding proteins is evolutionarily conserved, and regulates tissue-specific alternative splicing in metazoa. Fox-1 recognizes a (U)GCAUG stretch in regulated exons or in flanking introns. The protein binds to the C-terminus of ataxin-2 and may contribute to the restricted pathology of spinocerebellar ataxia type 2 (SCA2). Ataxin-2 is the product of the SCA2 gene which causes familial neurodegenerative diseases. Fox-1 and ataxin-2 are both localized in the trans-Golgi network. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Entrez Gene ID
54715
UniProt ID
Q9NWB1
Alternative Names
RNA Binding Fox-1 Homolog 1; RNA Binding Protein, Fox-1 Homolog 1; Hexaribonucleotide-Binding Protein 1; Ataxin 2-Binding Protein 1; Fox-1 Homolog A; HRNBP1; A2BP1; FOX1; Hexaribonucleotide Binding Protein 1 Isoform Alpha; RNA Binding Protein, Fox-1 Homolog (C. Elegans) 1;
Function
RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUGU-3' elements. Regulates alternative splicing of tissue-specific exons and of differentially spliced exons during erythropoiesis.
Biological Process
mRNA processing
Nervous system development
Regulation of alternative mRNA splicing, via spliceosome
RNA splicing
RNA transport
Cellular Location
Nucleus; Cytoplasm
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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