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Mouse Anti-RBFOX1 Recombinant Antibody (CBMAB-BR428LY)

The product is antibody recognizes RBFOX1. The antibody immunoassay techniques such as: IHC, WB.
See all RBFOX1 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Application
IHC: 1:300-1:500 dilution, WB: 0.1-0.5 μg/ml

Basic Information

Immunogen
N-terminal 100 amino acids of human Fox1 as expressed in and purified from E. coli.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
50% glycerol
Preservative
5mM sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
RNA binding protein fox-1 homolog 1
Introduction
The Fox-1 family of RNA-binding proteins is evolutionarily conserved, and regulates tissue-specific alternative splicing in metazoa. Fox-1 recognizes a (U)GCAUG stretch in regulated exons or in flanking introns. The protein binds to the C-terminus of ataxin-2 and may contribute to the restricted pathology of spinocerebellar ataxia type 2 (SCA2). Ataxin-2 is the product of the SCA2 gene which causes familial neurodegenerative diseases. Fox-1 and ataxin-2 are both localized in the trans-Golgi network. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Entrez Gene ID
Human54715
Mouse268859
Rat302920
UniProt ID
HumanQ9NWB1
MouseQ9JJ43
RatD3ZSL1
Alternative Names
RNA binding protein fox-1 homolog 1;Ataxin-2-binding protein 1;Fox-1 homolog A;Hexaribonucleotide-binding protein 1;RBFOX1;A2BP, A2BP1, FOX1, HRNBP1;
Function
RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUGU-3' elements. Regulates alternative splicing of tissue-specific exons and of differentially spliced exons during erythropoiesis.
Biological Process
mRNA processing
Nervous system development
Regulation of alternative mRNA splicing, via spliceosome
RNA splicing
RNA transport
Cellular Location
Nucleus; Cytoplasm
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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