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Mouse Anti-RBFOX2 Recombinant Antibody (5E11) (CBMAB-A7454-LY)

The product is antibody recognizes RBM9. The antibody 5E11 immunoassay techniques such as: WB, ELISA.
See all RBFOX2 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse
Clone
5E11
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
RBM9 (AAH13115, 1 a.a. ~ 100 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human, Mouse
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
RNA Binding Fox-1 Homolog 2
Introduction
This gene is one of several human genes similar to the C. elegans gene Fox-1. This gene encodes an RNA binding protein that is thought to be a key regulator of alternative exon splicing in the nervous system and other cell types. The protein binds to a conserved UGCAUG element found downstream of many alternatively spliced exons and promotes inclusion of the alternative exon in mature transcripts. The protein also interacts with the estrogen receptor 1 transcription factor and regulates estrogen receptor 1 transcriptional activity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
Entrez Gene ID
Human23543
Mouse93686
UniProt ID
HumanO43251
MouseQ8BP71
Alternative Names
FOX2; Fox-2; HNRBP2; HRNBP2; RTA; dJ106I20.3; fxh
Function
RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUGU-3' elements. Prevents binding of U2AF2 to the 3'-splice site. Regulates alternative splicing of tissue-specific exons and of differentially spliced exons during erythropoiesis (By similarity).
RNA-binding protein that seems to act as a coregulatory factor of ER-alpha.
Biological Process
Biological Process intracellular estrogen receptor signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process mRNA processingIEA:UniProtKB-KW
Biological Process negative regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process nervous system developmentManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of alternative mRNA splicing, via spliceosomeISS:BHF-UCL
Biological Process regulation of cell population proliferationManual Assertion Based On ExperimentTAS:UniProtKB
Biological Process RNA metabolic processManual Assertion Based On ExperimentTAS:UniProtKB
Biological Process RNA splicingIEA:UniProtKB-KW
Cellular Location
Nucleus
Cytoplasm
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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