RBFOX2

This gene is one of several human genes similar to the C. elegans gene Fox-1. This gene encodes an RNA binding protein that is thought to be a key regulator of alternative exon splicing in the nervous system and other cell types. The protein binds to a conserved UGCAUG element found downstream of many alternatively spliced exons and promotes inclusion of the alternative exon in mature transcripts. The protein also interacts with the estrogen receptor 1 transcription factor and regulates estrogen receptor 1 transcriptional activity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Full Name

RNA Binding Fox-1 Homolog 2

Function

RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUGU-3' elements. Prevents binding of U2AF2 to the 3'-splice site. Regulates alternative splicing of tissue-specific exons and of differentially spliced exons during erythropoiesis (By similarity).
RNA-binding protein that seems to act as a coregulatory factor of ER-alpha.

Biological Process

Biological Process intracellular estrogen receptor signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process mRNA processingIEA:UniProtKB-KW
Biological Process negative regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process nervous system developmentManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of alternative mRNA splicing, via spliceosomeISS:BHF-UCL
Biological Process regulation of cell population proliferationManual Assertion Based On ExperimentTAS:UniProtKB
Biological Process RNA metabolic processManual Assertion Based On ExperimentTAS:UniProtKB
Biological Process RNA splicingIEA:UniProtKB-KW

Cellular Location

Nucleus
Cytoplasm