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Mouse Anti-RBL2 Recombinant Antibody (130P215) (CBMAB-P3599-YC)

Provided herein is a Mouse monoclonal antibody against Human RB Transcriptional Corepressor Like 2. The antibody can be used for immunoassay techniques, such as IHC, IHC-P.
See all RBL2 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Rat
Clone
130P215
Antibody Isotype
IgG1
Application
IHC, IHC-P

Basic Information

Immunogen
Synthetic peptide: QCPELMMDRHLDQLLMCAIYVMAKVTKEDKSFQNIM, corresponding to amino acids 878-913 of Human p130
Specificity
Human, Rat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
RB Transcriptional Corepressor Like 2
Introduction
RBL2 has ubiquitous expression in lymph node (RPKM 41.9), testis (RPKM 38.9) and 25 other tissues.
Entrez Gene ID
Human5934
Rat81758
UniProt ID
HumanQ08999
RatO55081
Alternative Names
P130; Rb2
Function
Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor.
Biological Process
Biological Process cell cycleIEA:UniProtKB-KW
Biological Process cell differentiationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process chromatin organizationIEA:UniProtKB-KW
Biological Process negative regulation of G1/S transition of mitotic cell cycleManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of gene expressionManual Assertion Based On ExperimentIMP:MGI
Biological Process regulation of cell divisionIEA:InterPro
Biological Process regulation of lipid kinase activityManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of transcription by RNA polymerase IIIEA:InterPro
Cellular Location
Nucleus
PTM
During G0 and early G1 phase of the cell cycle, phosphorylated on Ser-639 and on 5 sites within the domain B. Phosphorylation on Ser-672 in G1 leads to its ubiquitin-dependent proteolysis.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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