RBL2

RBL2 has ubiquitous expression in lymph node (RPKM 41.9), testis (RPKM 38.9) and 25 other tissues.
Full Name
RB Transcriptional Corepressor Like 2
Function
Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor.
Biological Process
Biological Process cell cycleIEA:UniProtKB-KW
Biological Process cell differentiationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process chromatin organizationIEA:UniProtKB-KW
Biological Process negative regulation of G1/S transition of mitotic cell cycleManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of gene expressionManual Assertion Based On ExperimentIMP:MGI
Biological Process regulation of cell divisionIEA:InterPro
Biological Process regulation of lipid kinase activityManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of transcription by RNA polymerase IIIEA:InterPro
Cellular Location
Nucleus
PTM
During G0 and early G1 phase of the cell cycle, phosphorylated on Ser-639 and on 5 sites within the domain B. Phosphorylation on Ser-672 in G1 leads to its ubiquitin-dependent proteolysis.
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Anti-RBL2 antibodies

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Mouse Anti-RBL2 Recombinant Antibody (130P215) (CBMAB-P3599-YC)

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Target: RBL2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat
Clone: 130P215
Application*: IH, P
Datasheet SDS

Mouse Anti-RBL2 Recombinant Antibody (SPM301) (CBMAB-R1715-CN)

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Target: RBL2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: SPM301
Application*: IF, P, IP, WB
Datasheet SDS

Mouse Anti-RBL2 Recombinant Antibody (KAB40) (CBMAB-R1714-CN)

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Target: RBL2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse, Human, Monkey
Clone: KAB40
Application*: WB
Datasheet SDS

Mouse Anti-RBL2 Recombinant Antibody (DCS211.6) (CBMAB-R1713-CN)

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Target: RBL2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: DCS211.6
Application*: WB
Datasheet SDS

Mouse Anti-RBL2 Recombinant Antibody (DCS-211) (CBMAB-R1712-CN)

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Target: RBL2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: DCS-211
Application*: IF, IP, WB
Datasheet SDS

Rabbit Anti-RBL2 Recombinant Antibody (D9T7M) (CBMAB-R1711-CN)

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Target: RBL2
Host: Rabbit
Specificity: Human, Mouse, Rat, Monkey
Clone: D9T7M
Application*: WB, IP, CI
Datasheet SDS

Rabbit Anti-RBL2 Recombinant Antibody (CBCNR-296) (CBMAB-R1709-CN)

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Target: RBL2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBCNR-296
Application*: WB, IH, F
Datasheet SDS

Mouse Anti-RBL2 Recombinant Antibody (3F327) (CBMAB-R1707-CN)

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Target: RBL2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat
Clone: 3F327
Application*: IF, IH, IP, WB
Datasheet SDS

Mouse Anti-RBL2 Recombinant Antibody (3E3) (CBMAB-R1706-CN)

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Target: RBL2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3E3
Application*: WB, E
Datasheet SDS

Mouse Anti-RBL2 Recombinant Antibody (2C8A8) (CBMAB-R1704-CN)

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Target: RBL2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2C8A8
Application*: E, WB, P, IF, F
Datasheet SDS

Mouse Anti-RBL2 Recombinant Antibody (1E2) (CBMAB-R1702-CN)

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Target: RBL2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse
Clone: 1E2
Application*: E, WB
Datasheet SDS

rabbit Anti-RBL2 Recombinant Antibody (13A217) (CBMAB-R1701-CN)

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Target: RBL2
Host: rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 13A217
Application*: F, IH, WB
Datasheet SDS

Mouse Anti-RBL2 Recombinant Antibody (10/Rb2) (CBMAB-R1700-CN)

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Target: RBL2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Chicken, Mouse, Rat
Clone: 10/Rb2
Application*: WB, IF, IH
Datasheet SDS

Mouse Anti-RBL2 Recombinant Antibody (CBT3127) (V2LY-0625-LY211)

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Target: RBL2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3127
Application*: F
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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