Mouse Anti-RBL2 Recombinant Antibody (DCS-211) (CBMAB-R1712-CN)

Name: Mouse Anti-RBL2 Recombinant Antibody (DCS-211)
SKU: CBMAB-R1712-CN
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

DCS-211

Application

IF, IP, WB

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Preservative

No preservatives

More Infomation

Target

Full Name

RB Transcriptional Corepressor Like 2

Entrez Gene ID

5934

UniProt ID

Q08999

Alternative Names

RB Transcriptional Corepressor Like 2; 130 KDa Retinoblastoma-Associated Protein; Retinoblastoma-Related Protein 2; Retinoblastoma-Like 2; RBR-2; P130; PRB2; Rb2; Retinoblastoma-Like Protein 2;

Function

Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor.

Biological Process

Biological Process cell cycleIEA:UniProtKB-KW
Biological Process cell differentiationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process chromatin organizationIEA:UniProtKB-KW
Biological Process negative regulation of G1/S transition of mitotic cell cycleManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of gene expressionManual Assertion Based On ExperimentIMP:MGI
Biological Process regulation of cell divisionIEA:InterPro
Biological Process regulation of lipid kinase activityManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of transcription by RNA polymerase IIIEA:InterPro

Cellular Location

Nucleus

PTM

During G0 and early G1 phase of the cell cycle, phosphorylated on Ser-639 and on 5 sites within the domain B. Phosphorylation on Ser-672 in G1 leads to its ubiquitin-dependent proteolysis.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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