Mouse Anti-RBPMS Recombinant Antibody (1C12) (CBMAB-R1897-CN)

Name: Mouse Anti-RBPMS Recombinant Antibody (1C12)
SKU: CBMAB-R1897-CN
Rating: 5 (1 reviews)

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Datasheet

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Basic Information

Host Animal

Mouse

Clone

1C12

Application

ELISA, WB

Immunogen

Full length recombinant corresponding to aa. 1-220 from human RBPMS (H03608) with GST tag

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.2

More Infomation

Target

Full Name

RNA binding protein with multiple splicing

Introduction

This gene encodes a member of the RNA recognition motif family of RNA-binding proteins. The RNA recognition motif is between 80-100 amino acids in length and family members contain one to four copies of the motif. The RNA recognition motif consists of two short stretches of conserved sequence, as well as a few highly conserved hydrophobic residues. The encoded protein has a single, putative RNA recognition motif in its N-terminus. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2013]

Entrez Gene ID

11030

UniProt ID

Q93062

Alternative Names

RNA Binding Protein, MRNA Processing Factor; RNA Binding Protein With Multiple Splicing; Heart And RRM Expressed Sequence; HERMES; RNA-Binding Protein With Multiple Splicing; RBP-MS;

Function

Acts as a coactivator of transcriptional activity. Required to increase TGFB1/Smad-mediated transactivation. Acts through SMAD2, SMAD3 and SMAD4 to increase transcriptional activity. Increases phosphorylation of SMAD2 and SMAD3 on their C-terminal SSXS motif, possibly through recruitment of TGFBR1. Promotes the nuclear accumulation of SMAD2, SMAD3 and SMAD4 proteins (PubMed:26347403).
Binds to poly(A) RNA (PubMed:17099224, PubMed:26347403).

Biological Process

Biological Process positive regulation of pathway-restricted SMAD protein phosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of SMAD protein signal transductionManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process response to oxidative stressManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process RNA processingManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Nucleus
Cytoplasm
Cytoplasm, P-body
Translocates into cytoplasmic stress granules that probably correspond to P-bodies in response to oxidative stress.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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