RBPMS

This gene encodes a member of the RRM family of RNA-binding proteins. The RRM domain is between 80-100 amino acids in length and family members contain one to four copies of the domain. The RRM domain consists of two short stretches of conserved sequence called RNP1 and RNP2, as well as a few highly conserved hydrophobic residues. The protein encoded by this gene has a single, putative RRM domain in its N-terminus. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq]

RNA binding protein with multiple splicing

Acts as a coactivator of transcriptional activity. Required to increase TGFB1/Smad-mediated transactivation. Acts through SMAD2, SMAD3 and SMAD4 to increase transcriptional activity. Increases phosphorylation of SMAD2 and SMAD3 on their C-terminal SSXS motif, possibly through recruitment of TGFBR1. Promotes the nuclear accumulation of SMAD2, SMAD3 and SMAD4 proteins (PubMed:26347403).
Binds to poly(A) RNA (PubMed:17099224, PubMed:26347403).

Biological Process positive regulation of pathway-restricted SMAD protein phosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of SMAD protein signal transductionManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process response to oxidative stressManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process RNA processingManual Assertion Based On ExperimentTAS:ProtInc

Nucleus
Cytoplasm
Cytoplasm, P-body
Translocates into cytoplasmic stress granules that probably correspond to P-bodies in response to oxidative stress.