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Mouse Anti-RBPMS Recombinant Antibody (2G10) (CBMAB-R1900-CN)

This product is a Mouse antibody that recognizes RBPMS. The antibody 2G10 can be used for immunoassay techniques such as: WB, IHC, FC.
See all RBPMS antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2G10
Antibody Isotype
IgG1
Application
WB, IHC, FC

Basic Information

Immunogen
Full length human recombinant protein of human RBPMS (NP_001008712) produced in E.coli
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.3, 1% BSA, 50% Glycerol
Preservative
0.02% Sodium azide
Concentration
1 mg/mL

Target

Full Name
RNA binding protein with multiple splicing
Introduction
This gene encodes a member of the RNA recognition motif family of RNA-binding proteins. The RNA recognition motif is between 80-100 amino acids in length and family members contain one to four copies of the motif. The RNA recognition motif consists of two short stretches of conserved sequence, as well as a few highly conserved hydrophobic residues. The encoded protein has a single, putative RNA recognition motif in its N-terminus. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2013]
Entrez Gene ID
11030
UniProt ID
Q93062
Alternative Names
RNA Binding Protein, MRNA Processing Factor; RNA Binding Protein With Multiple Splicing; Heart And RRM Expressed Sequence; HERMES; RNA-Binding Protein With Multiple Splicing; RBP-MS;
Function
Acts as a coactivator of transcriptional activity. Required to increase TGFB1/Smad-mediated transactivation. Acts through SMAD2, SMAD3 and SMAD4 to increase transcriptional activity. Increases phosphorylation of SMAD2 and SMAD3 on their C-terminal SSXS motif, possibly through recruitment of TGFBR1. Promotes the nuclear accumulation of SMAD2, SMAD3 and SMAD4 proteins (PubMed:26347403).
Binds to poly(A) RNA (PubMed:17099224, PubMed:26347403).
Biological Process
Biological Process positive regulation of pathway-restricted SMAD protein phosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of SMAD protein signal transductionManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process response to oxidative stressManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process RNA processingManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Nucleus
Cytoplasm
Cytoplasm, P-body
Translocates into cytoplasmic stress granules that probably correspond to P-bodies in response to oxidative stress.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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