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Rabbit Anti-RCC1 Recombinant Antibody (D15H6) (CBMAB-R1928-CN)

This product is a Rabbit antibody that recognizes RCC1. The antibody D15H6 can be used for immunoassay techniques such as: WB, IF.
See all RCC1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat, Monkey
Clone
D15H6
Antibody Isotype
IgG
Application
WB, IF

Basic Information

Specificity
Human, Mouse, Rat, Monkey
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Target

Full Name
Regulator Of Chromosome Condensation 1
Introduction
RCC1 (Regulator Of Chromosome Condensation 1) is a Protein Coding gene. Diseases associated with RCC1 include Renal-Hepatic-Pancreatic Dysplasia and Retinitis Pigmentosa. Among its related pathways are Transport of the SLBP independent Mature mRNA and DNA Damage. Gene Ontology (GO) annotations related to this gene include chromatin binding and nucleosomal DNA binding. An important paralog of this gene is RPGR.
Entrez Gene ID
Human1104
Mouse100088
Rat682908
Monkey720265
UniProt ID
HumanP18754
MouseQ8VE37
RatB1H227
MonkeyF7H672
Alternative Names
Regulator Of Chromosome Condensation 1; Cell Cycle Regulatory Protein; CHC1; Guanine Nucleotide-Releasing Protein; Regulator Of Chromosome Condensation; Chromosome Condensation Protein 1;
Function
Guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP by GTP, and thereby plays an important role in RAN-mediated functions in nuclear import and mitosis (PubMed:1944575, PubMed:17435751, PubMed:20668449, PubMed:22215983, PubMed:11336674).
Contributes to the generation of high levels of chromosome-associated, GTP-bound RAN, which is important for mitotic spindle assembly and normal progress through mitosis (PubMed:12194828, PubMed:17435751, PubMed:22215983).
Via its role in maintaining high levels of GTP-bound RAN in the nucleus, contributes to the release of cargo proteins from importins after nuclear import (PubMed:22215983).
Involved in the regulation of onset of chromosome condensation in the S phase (PubMed:3678831).
Binds both to the nucleosomes and double-stranded DNA (PubMed:17435751, PubMed:18762580).
Biological Process
Cell divisionIEA:UniProtKB-KW
Chromosome segregationManual Assertion Based On ExperimentIMP:UniProtKB
G1/S transition of mitotic cell cycleManual Assertion Based On ExperimentIMP:UniProtKB
Mitotic nuclear membrane reassemblyTAS:Reactome
Mitotic spindle organizationManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of mitotic nuclear divisionManual Assertion Based On ExperimentIDA:UniProtKB
Spindle assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Viral processTAS:Reactome
Cellular Location
Nucleus
Chromosome
Cytoplasm
Predominantly nuclear in interphase cells (PubMed:12194828).
Binds to mitotic chromosomes (PubMed:12194828, PubMed:17435751, PubMed:20668449).
PTM
N-terminal methylation by METTL11A/NTM1 is required for binding double-stranded DNA and stable chromatin association. Di- and trimethylation produce a permanent positive charge on the amino group, which facilitates electrostatic binding to the phosphate groups on DNA, while inhibiting histone-binding. Methylated tail helps retain RCC1 on chromosomes during nucleotide exchange on Ran.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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