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Mouse Anti-RETN Recombinant Antibody (5E8) (CBMAB-R2250-CN)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
5E8
Antibody Isotype
IgG2b, κ
Application
ELISA, WB

Basic Information

Immunogen
Full length recombinant corresponding to aa. 20-106 from human RETN (NP_065148) with GST tag
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2

Target

Introduction
This gene belongs to the family defined by the mouse resistin-like genes. The characteristic feature of this family is the C-terminal stretch of 10 cys residues with identical spacing. The mouse homolog of this protein is secreted by adipocytes, and may be the hormone potentially linking obesity to type II diabetes. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2010]
Entrez Gene ID
56729
UniProt ID
Q9HD89
Alternative Names
Resistin; C/EBP-Epsilon-Regulated Myeloid-Specific Secreted Cysteine-Rich Protein; Cysteine-Rich Secreted Protein A12-Alpha-Like 2; Adipose Tissue-Specific Secretory Factor; Cysteine-Rich Secreted Protein FIZZ3; FIZZ3; ADSF; RSTN;
Function
Hormone that seems to suppress insulin ability to stimulate glucose uptake into adipose cells (By similarity).
Potentially links obesity to diabetes (By similarity).
Promotes chemotaxis in myeloid cells (PubMed:15064728).
Biological Process
Biological Process agingIEA:Ensembl
Biological Process fat cell differentiationIEA:Ensembl
Biological Process negative regulation of feeding behaviorIEA:Ensembl
Biological Process positive regulation of progesterone secretionIEA:Ensembl
Biological Process positive regulation of synaptic transmissionIEA:Ensembl
Biological Process response to insulinIEA:Ensembl
Biological Process response to mechanical stimulusIEA:Ensembl
Cellular Location
Secreted
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For research use only. Not intended for any clinical use.

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