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Mouse Anti-RFNG Recombinant Antibody (9G432) (CBMAB-R2343-CN)

This product is a Mouse antibody that recognizes RFNG. The antibody 9G432 can be used for immunoassay techniques such as: ELISA, IF, WB.
See all RFNG antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
9G432
Antibody Isotype
IgG
Application
ELISA, IF, WB

Basic Information

Immunogen
Partial recombinant human radical fringe homolog (aa. 222-330) with a GST tag
Specificity
Human
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
LYOPH
Buffer
PBS, pH 7.2

Target

Full Name
RFNG O-Fucosylpeptide 3-Beta-N-Acetylglucosaminyltransferase
Introduction
RFNG (RFNG O-Fucosylpeptide 3-Beta-N-Acetylglucosaminyltransferase) is a Protein Coding gene. Diseases associated with RFNG include Renal Cell Carcinoma, Papillary, 1. Among its related pathways are Development NOTCH1-mediated pathway for NF-KB activity modulation and PI3K-Akt signaling pathway. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring glycosyl groups and O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity. An important paralog of this gene is LFNG.
Entrez Gene ID
5986
UniProt ID
Q9Y644
Alternative Names
RFNG O-Fucosylpeptide 3-Beta-N-Acetylglucosaminyltransferase; EC 2.4.1.222; O-Fucosylpeptide 3-Beta-N-Acetylglucosaminyltransferase; Radical Fringe (Drosophila) Homolog; Radical Fringe Homolog (Drosophila);
Function
Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Modulates NOTCH1 activity by modifying O-fucose residues at specific EGF-like domains resulting in enhancement of NOTCH1 activation by DLL1 and JAG1. May be involved in limb formation and in neurogenesis.
Biological Process
Biological Process animal organ morphogenesis1 PublicationNAS:UniProtKB
Biological Process cell differentiationIEA:UniProtKB-KW
Biological Process nervous system developmentIEA:UniProtKB-KW
Biological Process pattern specification processIEA:InterPro
Biological Process positive regulation of Notch signaling pathwayIEA:Ensembl
Biological Process positive regulation of protein bindingIEA:Ensembl
Biological Process regulation of Notch signaling pathwayISS:UniProtKB
Cellular Location
Golgi apparatus membrane
Topology
Cytoplasmic: 1-6
Helical: 7-29
Lumenal: 30-331
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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