Mouse Anti-RFNG Recombinant Antibody (9G432) (CBMAB-R2343-CN)

Name: Mouse Anti-RFNG Recombinant Antibody (9G432)
SKU: CBMAB-R2343-CN
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

9G432

Application

ELISA, IF, WB

Immunogen

Partial recombinant human radical fringe homolog (aa. 222-330) with a GST tag

Specificity

Human

Antibody Isotype

IgG

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

LYOPH

Buffer

PBS, pH 7.2

More Infomation

Target

Full Name

RFNG O-Fucosylpeptide 3-Beta-N-Acetylglucosaminyltransferase

Introduction

RFNG (RFNG O-Fucosylpeptide 3-Beta-N-Acetylglucosaminyltransferase) is a Protein Coding gene. Diseases associated with RFNG include Renal Cell Carcinoma, Papillary, 1. Among its related pathways are Development NOTCH1-mediated pathway for NF-KB activity modulation and PI3K-Akt signaling pathway. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring glycosyl groups and O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity. An important paralog of this gene is LFNG.

Entrez Gene ID

5986

UniProt ID

Q9Y644

Alternative Names

RFNG O-Fucosylpeptide 3-Beta-N-Acetylglucosaminyltransferase; EC 2.4.1.222; O-Fucosylpeptide 3-Beta-N-Acetylglucosaminyltransferase; Radical Fringe (Drosophila) Homolog; Radical Fringe Homolog (Drosophila);

Function

Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Modulates NOTCH1 activity by modifying O-fucose residues at specific EGF-like domains resulting in enhancement of NOTCH1 activation by DLL1 and JAG1. May be involved in limb formation and in neurogenesis.

Biological Process

Biological Process animal organ morphogenesis1 PublicationNAS:UniProtKB
Biological Process cell differentiationIEA:UniProtKB-KW
Biological Process nervous system developmentIEA:UniProtKB-KW
Biological Process pattern specification processIEA:InterPro
Biological Process positive regulation of Notch signaling pathwayIEA:Ensembl
Biological Process positive regulation of protein bindingIEA:Ensembl
Biological Process regulation of Notch signaling pathwayISS:UniProtKB

Cellular Location

Golgi apparatus membrane

Topology

Cytoplasmic: 1-6
Helical: 7-29
Lumenal: 30-331

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

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Mouse Anti-RFNG Recombinant Antibody (CBCNR-139) (CAT#: CBMAB-R2344-CN)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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