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RFNG

RFNG (RFNG O-Fucosylpeptide 3-Beta-N-Acetylglucosaminyltransferase) is a Protein Coding gene. Diseases associated with RFNG include Renal Cell Carcinoma, Papillary, 1. Among its related pathways are Development NOTCH1-mediated pathway for NF-KB activity modulation and PI3K-Akt signaling pathway. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring glycosyl groups and O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity. An important paralog of this gene is LFNG.

Full Name

RFNG O-Fucosylpeptide 3-Beta-N-Acetylglucosaminyltransferase

Function

Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Modulates NOTCH1 activity by modifying O-fucose residues at specific EGF-like domains resulting in enhancement of NOTCH1 activation by DLL1 and JAG1. May be involved in limb formation and in neurogenesis.

Biological Process

Biological Process animal organ morphogenesis1 PublicationNAS:UniProtKB
Biological Process cell differentiationIEA:UniProtKB-KW
Biological Process nervous system developmentIEA:UniProtKB-KW
Biological Process pattern specification processIEA:InterPro
Biological Process positive regulation of Notch signaling pathwayIEA:Ensembl
Biological Process positive regulation of protein bindingIEA:Ensembl
Biological Process regulation of Notch signaling pathwayISS:UniProtKB

Cellular Location

Golgi apparatus membrane

Topology

Cytoplasmic: 1-6
Helical: 7-29
Lumenal: 30-331

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Anti-RFNG antibodies

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Human RFNG ELISA Kit (V2LY-0626-LY2372)

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Target: RFNG

Sensitivity: 0.01 ng/mL

Detection Range: 0.02-4.5 ng/mL

Sample Type: Serum, Plasma, cell culture supernates

Specificity: Human

Assay Type: Sandwich

Reactivity: Human

Mouse Anti-RFNG Recombinant Antibody (CBCNR-139) (CBMAB-R2344-CN)

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Target: RFNG

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBCNR-139

Application*: WB

Mouse Anti-RFNG Recombinant Antibody (9G432) (CBMAB-R2343-CN)

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Target: RFNG

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: 9G432

Application*: E, IF, WB

Mouse Anti-RFNG Recombinant Antibody (6C7) (CBMAB-R2342-CN)

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Target: RFNG

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 6C7

Application*: E, IF, WB

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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