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Mouse Anti-RFTN1 Recombinant Antibody (E-11) (CBMAB-R2375-CN)

This product is a Mouse antibody that recognizes RFTN1. The antibody E-11 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all RFTN1 antibodies

Summary

Host Animal
Mouse
Specificity
Mouse
Clone
E-11
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Mouse
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Target

Full Name
Raftlin, Lipid Raft Linker 1
Introduction
RFTN1 (Raftlin, Lipid Raft Linker 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include double-stranded RNA binding. An important paralog of this gene is RFTN2.
Entrez Gene ID
76438
UniProt ID
6A0D4
Alternative Names
Raftlin, Lipid Raft Linker 1; Raft-Linking Protein; Cell Migration-Inducing Gene 2 Protein; Proliferation-Inducing Protein 10; Proliferation-Inducing Protein 9; KIAA0084;
Function
Involved in protein trafficking via association with clathrin and AP2 complex (PubMed:27022195, PubMed:21266579).
Upon bacterial lipopolysaccharide stimulation, mediates internalization of TLR4 to endosomes in dendritic cells and macrophages; and internalization of poly(I:C) to TLR3-positive endosomes in myeloid dendritic cells and epithelial cells; resulting in activation of TICAM1-mediated signaling and subsequent IFNB1 production (PubMed:27022195, PubMed:21266579).
Involved in T-cell antigen receptor-mediated signaling by regulating tyrosine kinase LCK localization, T-cell dependent antibody production and cytokine secretion (By similarity).
May regulate B-cell antigen receptor-mediated signaling (PubMed:12805216).
May play a pivotal role in the formation and/or maintenance of lipid rafts (PubMed:12805216).
Biological Process
Biological Process B cell receptor signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process dsRNA transportManual Assertion Based On ExperimentIMP:MGI
Biological Process membrane raft assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of growth rateManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of interleukin-17 productionISS:UniProtKB
Biological Process protein localization to membrane raftISS:CAFA
Biological Process protein transport into membrane raftISS:CAFA
Biological Process response to exogenous dsRNAManual Assertion Based On ExperimentIMP:MGI
Biological Process T cell antigen processing and presentationISS:CAFA
Biological Process T cell receptor signaling pathwayISS:CAFA
Biological Process toll-like receptor 3 signaling pathwayManual Assertion Based On ExperimentIMP:MGI
Cellular Location
Cell membrane
Cytoplasm
Membrane raft
Endosome
Early endosome
Translocates from cytoplasm to cell membrane where it colocalizes with poly (I:C) and then moves to endosomes where it colocalizes with TLR3 (PubMed:21266579).
Translocates from cytoplasm to cell membrane where it colocalizes with TLR4 and then together with TLR4 moves to endosomes, upon lipopolysaccharide stimulation (PubMed:27022195).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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