RFTN1

RFTN1 (Raftlin, Lipid Raft Linker 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include double-stranded RNA binding. An important paralog of this gene is RFTN2.

Full Name

Raftlin, Lipid Raft Linker 1

Function

Involved in protein trafficking via association with clathrin and AP2 complex (PubMed:27022195, PubMed:21266579).
Upon bacterial lipopolysaccharide stimulation, mediates internalization of TLR4 to endosomes in dendritic cells and macrophages; and internalization of poly(I:C) to TLR3-positive endosomes in myeloid dendritic cells and epithelial cells; resulting in activation of TICAM1-mediated signaling and subsequent IFNB1 production (PubMed:27022195, PubMed:21266579).
Involved in T-cell antigen receptor-mediated signaling by regulating tyrosine kinase LCK localization, T-cell dependent antibody production and cytokine secretion (By similarity).
May regulate B-cell antigen receptor-mediated signaling (PubMed:12805216).
May play a pivotal role in the formation and/or maintenance of lipid rafts (PubMed:12805216).

Biological Process

Biological Process B cell receptor signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process dsRNA transportManual Assertion Based On ExperimentIMP:MGI
Biological Process membrane raft assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of growth rateManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of interleukin-17 productionISS:UniProtKB
Biological Process protein localization to membrane raftISS:CAFA
Biological Process protein transport into membrane raftISS:CAFA
Biological Process response to exogenous dsRNAManual Assertion Based On ExperimentIMP:MGI
Biological Process T cell antigen processing and presentationISS:CAFA
Biological Process T cell receptor signaling pathwayISS:CAFA
Biological Process toll-like receptor 3 signaling pathwayManual Assertion Based On ExperimentIMP:MGI

Cellular Location

Cell membrane
Cytoplasm
Membrane raft
Endosome
Early endosome
Translocates from cytoplasm to cell membrane where it colocalizes with poly (I:C) and then moves to endosomes where it colocalizes with TLR3 (PubMed:21266579).
Translocates from cytoplasm to cell membrane where it colocalizes with TLR4 and then together with TLR4 moves to endosomes, upon lipopolysaccharide stimulation (PubMed:27022195).