Mouse Anti-RFTN1 Recombinant Antibody (H-3) (CBMAB-R2376-CN)
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Basic Information
Target
Upon bacterial lipopolysaccharide stimulation, mediates internalization of TLR4 to endosomes in dendritic cells and macrophages; and internalization of poly(I:C) to TLR3-positive endosomes in myeloid dendritic cells and epithelial cells; resulting in activation of TICAM1-mediated signaling and subsequent IFNB1 production (PubMed:27022195, PubMed:21266579).
Involved in T-cell antigen receptor-mediated signaling by regulating tyrosine kinase LCK localization, T-cell dependent antibody production and cytokine secretion (By similarity).
May regulate B-cell antigen receptor-mediated signaling (PubMed:12805216).
May play a pivotal role in the formation and/or maintenance of lipid rafts (PubMed:12805216).
Biological Process dsRNA transportManual Assertion Based On ExperimentIMP:MGI
Biological Process membrane raft assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of growth rateManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of interleukin-17 productionISS:UniProtKB
Biological Process protein localization to membrane raftISS:CAFA
Biological Process protein transport into membrane raftISS:CAFA
Biological Process response to exogenous dsRNAManual Assertion Based On ExperimentIMP:MGI
Biological Process T cell antigen processing and presentationISS:CAFA
Biological Process T cell receptor signaling pathwayISS:CAFA
Biological Process toll-like receptor 3 signaling pathwayManual Assertion Based On ExperimentIMP:MGI
Cytoplasm
Membrane raft
Endosome
Early endosome
Translocates from cytoplasm to cell membrane where it colocalizes with poly (I:C) and then moves to endosomes where it colocalizes with TLR3 (PubMed:21266579).
Translocates from cytoplasm to cell membrane where it colocalizes with TLR4 and then together with TLR4 moves to endosomes, upon lipopolysaccharide stimulation (PubMed:27022195).
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Please try the standard protocols which include: protocols, troubleshooting and guide.
Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols
Custom Antibody Labeling
We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).
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