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Mouse Anti-RGS3 Recombinant Antibody (1E8-C7) (CBMAB-R2454-CN)

This product is a Mouse antibody that recognizes RGS3. The antibody 1E8-C7 can be used for immunoassay techniques such as: WB, ELISA, IHC-P, IF.
See all RGS3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1E8-C7
Antibody Isotype
IgG1
Application
WB, ELISA, IHC-P, IF

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration
0.45 mg/mL

Target

Full Name
Regulator Of G Protein Signaling 3
Introduction
This gene encodes a member of the regulator of G-protein signaling (RGS) family. This protein is a GTPase-activating protein that inhibits G-protein-mediated signal transduction. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms. Long isoforms are largely cytosolic and plasma membrane-associated with a function in Wnt signaling and in the epithelial mesenchymal transition, while shorter N-terminally-truncated isoforms can be nuclear. [provided by RefSeq, Jan 2013]
Entrez Gene ID
5998
UniProt ID
P49796
Alternative Names
Regulator Of G Protein Signaling 3; Regulator Of G-Protein Signalling 3; Regulator Of G-Protein Signaling 3; RGP3; C2PA;
Function
Down-regulates signaling from heterotrimeric G-proteins by increasing the GTPase activity of the alpha subunits, thereby driving them into their inactive GDP-bound form. Down-regulates G-protein-mediated release of inositol phosphates and activation of MAP kinases.
Biological Process
Biological Process G protein-coupled receptor signaling pathwayTAS:Reactome
Biological Process negative regulation of signal transductionIEA:UniProtKB-KW
Biological Process regulation of G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Biological Process signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cytoplasm
Nucleus
Cell membrane
Long isoforms are cytoplasmic and associated with the plasma membrane (PubMed:9858594).
Short isoforms are nuclear (PubMed:10749886).
PTM
Phosphorylated by cyclic GMP-dependent protein kinase.
ISGylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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