Mouse Anti-RGS3 Recombinant Antibody (CBCNR-456) (CBMAB-R2456-CN)

Name: Mouse Anti-RGS3 Recombinant Antibody (CBCNR-456)
SKU: CBMAB-R2456-CN
Rating: 5 (1 reviews)

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Datasheet

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Basic Information

Host Animal

Mouse

Clone

CBCNR-456

Application

WB, IHC-P

Specificity

Human

Antibody Isotype

IgG1

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration

1 mg/mL

More Infomation

Target

Full Name

Regulator Of G Protein Signaling 3

Introduction

This gene encodes a member of the regulator of G-protein signaling (RGS) family. This protein is a GTPase-activating protein that inhibits G-protein-mediated signal transduction. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms. Long isoforms are largely cytosolic and plasma membrane-associated with a function in Wnt signaling and in the epithelial mesenchymal transition, while shorter N-terminally-truncated isoforms can be nuclear. [provided by RefSeq, Jan 2013]

Entrez Gene ID

5998

UniProt ID

P49796

Alternative Names

Regulator Of G Protein Signaling 3; Regulator Of G-Protein Signalling 3; Regulator Of G-Protein Signaling 3; RGP3; C2PA;

Function

Down-regulates signaling from heterotrimeric G-proteins by increasing the GTPase activity of the alpha subunits, thereby driving them into their inactive GDP-bound form. Down-regulates G-protein-mediated release of inositol phosphates and activation of MAP kinases.

Biological Process

Biological Process G protein-coupled receptor signaling pathwayTAS:Reactome
Biological Process negative regulation of signal transductionIEA:UniProtKB-KW
Biological Process regulation of G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Biological Process signal transductionManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Cytoplasm
Nucleus
Cell membrane
Long isoforms are cytoplasmic and associated with the plasma membrane (PubMed:9858594).
Short isoforms are nuclear (PubMed:10749886).

PTM

Phosphorylated by cyclic GMP-dependent protein kinase.
ISGylated.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Antibody Pairs

RGS3 Matched Antibody Pair (990) (CAT#: APMAB-990LY)

RGS3 Matched Antibody Pair (991) (CAT#: APMAB-991LY)

Related Products

Mouse Anti-RGS3 Recombinant Antibody (CBCNR-455) (CAT#: CBMAB-R2455-CN)

Mouse Anti-RGS3 Recombinant Antibody (1E8-C7) (CAT#: CBMAB-R2454-CN)

RGS3 Matched Antibody Pair (990) (CAT#: APMAB-990LY)

RGS3 Matched Antibody Pair (991) (CAT#: APMAB-991LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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