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RGS3

This gene encodes a member of the regulator of G-protein signaling (RGS) family. This protein is a GTPase-activating protein that inhibits G-protein-mediated signal transduction. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms. Long isoforms are largely cytosolic and plasma membrane-associated with a function in Wnt signaling and in the epithelial mesenchymal transition, while shorter N-terminally-truncated isoforms can be nuclear. [provided by RefSeq, Jan 2013]
Full Name
Regulator Of G Protein Signaling 3
Function
Down-regulates signaling from heterotrimeric G-proteins by increasing the GTPase activity of the alpha subunits, thereby driving them into their inactive GDP-bound form. Down-regulates G-protein-mediated release of inositol phosphates and activation of MAP kinases.
Biological Process
Biological Process G protein-coupled receptor signaling pathwayTAS:Reactome
Biological Process negative regulation of signal transductionIEA:UniProtKB-KW
Biological Process regulation of G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Biological Process signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cytoplasm
Nucleus
Cell membrane
Long isoforms are cytoplasmic and associated with the plasma membrane (PubMed:9858594).
Short isoforms are nuclear (PubMed:10749886).
PTM
Phosphorylated by cyclic GMP-dependent protein kinase.
ISGylated.
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Anti-RGS3 antibodies

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Mouse Anti-RGS3 Recombinant Antibody (1E8-C7) (CBMAB-R2454-CN)

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Target: RGS3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1E8-C7
Application*: WB, E, P, IF
Datasheet SDS

RGS3 Matched Antibody Pair (991) (APMAB-991LY)

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Target: RGS3
Specificity: Human
Datasheet SDS

RGS3 Matched Antibody Pair (990) (APMAB-990LY)

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Target: RGS3
Specificity: Human
Datasheet SDS

Mouse Anti-RGS3 Recombinant Antibody (CBCNR-456) (CBMAB-R2456-CN)

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Target: RGS3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBCNR-456
Application*: WB, P
Datasheet SDS

Mouse Anti-RGS3 Recombinant Antibody (CBCNR-455) (CBMAB-R2455-CN)

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Target: RGS3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBCNR-455
Application*: E, WB, P, IF
Datasheet SDS
More Infomation
Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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