loading...

RGS3

This gene encodes a member of the regulator of G-protein signaling (RGS) family. This protein is a GTPase-activating protein that inhibits G-protein-mediated signal transduction. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms. Long isoforms are largely cytosolic and plasma membrane-associated with a function in Wnt signaling and in the epithelial mesenchymal transition, while shorter N-terminally-truncated isoforms can be nuclear. [provided by RefSeq, Jan 2013]

Full Name

Regulator Of G Protein Signaling 3

Function

Down-regulates signaling from heterotrimeric G-proteins by increasing the GTPase activity of the alpha subunits, thereby driving them into their inactive GDP-bound form. Down-regulates G-protein-mediated release of inositol phosphates and activation of MAP kinases.

Biological Process

Biological Process G protein-coupled receptor signaling pathwayTAS:Reactome
Biological Process negative regulation of signal transductionIEA:UniProtKB-KW
Biological Process regulation of G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Biological Process signal transductionManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Cytoplasm
Nucleus
Cell membrane
Long isoforms are cytoplasmic and associated with the plasma membrane (PubMed:9858594).
Short isoforms are nuclear (PubMed:10749886).

PTM

Phosphorylated by cyclic GMP-dependent protein kinase.
ISGylated.

View more

Anti-RGS3 antibodies

+ Filters

Loading...

Mouse Anti-RGS3 Recombinant Antibody (1E8-C7) (CBMAB-R2454-CN)

Compare

Target: RGS3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 1E8-C7

Application*: WB, E, P, IF

RGS3 Matched Antibody Pair (991) (APMAB-991LY)

Compare

Target: RGS3

Specificity: Human

RGS3 Matched Antibody Pair (990) (APMAB-990LY)

Compare

Target: RGS3

Specificity: Human

Mouse Anti-RGS3 Recombinant Antibody (CBCNR-456) (CBMAB-R2456-CN)

Compare

Target: RGS3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBCNR-456

Application*: WB, P

Mouse Anti-RGS3 Recombinant Antibody (CBCNR-455) (CBMAB-R2455-CN)

Compare

Target: RGS3

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBCNR-455

Application*: E, WB, P, IF

More Infomation

Submit A Review

Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

Submit A Review

Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

Hot products

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

online inquiry

Online Inquiry