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Mouse Anti-RGS9 Recombinant Antibody (D3) (CBMAB-R2470-CN)

This product is a Mouse antibody that recognizes RGS9. The antibody D3 can be used for immunoassay techniques such as: WB, IF, ELISA.
See all RGS9 antibodies

Summary

Host Animal
Mouse
Specificity
Mouse, Cattle
Clone
D3
Application
WB, IF, ELISA

Basic Information

Specificity
Mouse, Cattle
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Target

Full Name
Regulator Of G Protein Signaling 9
Introduction
This gene encodes a member of the RGS family of GTPase activating proteins that function in various signaling pathways by accelerating the deactivation of G proteins. This protein is anchored to photoreceptor membranes in retinal cells and deactivates G proteins in the rod and cone phototransduction cascades. Mutations in this gene result in bradyopsia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
Entrez Gene ID
Cattle281453
Mouse19739
UniProt ID
CattleO46469
MouseO54828
Alternative Names
Regulator Of G Protein Signaling 9; Regulator Of G-Protein Signalling 9; Regulator Of G-Protein Signaling 9; Regulator Of G Protein Signalling 9L; Regulator Of G Protein Signalling 9; Regulator Of G-Protein Signaling 9L; PERRS; RGS9L;
Function
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to GNAT1. Involved in phototransduction; key element in the recovery phase of visual transduction (By similarity).
Biological Process
Biological Process dark adaptationIEA:Ensembl
Biological Process G protein-coupled receptor signaling pathwayTAS:Reactome
Biological Process intracellular signal transductionIEA:InterPro
Biological Process light adaptionIEA:Ensembl
Biological Process negative regulation of signal transductionIEA:UniProtKB-KW
Biological Process positive regulation of GTPase activityManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Biological Process visual perceptionIEA:UniProtKB-KW
Cellular Location
Isoform 3
Membrane
Isoform 3 is targeted to the membrane via its interaction with RGS9BP.
Involvement in disease
Prolonged electroretinal response suppression (PERRS):
Characterized by difficulty adjusting to sudden changes in luminance levels mediated by cones.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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