RGS9

This gene encodes a member of the RGS family of GTPase activating proteins that function in various signaling pathways by accelerating the deactivation of G proteins. This protein is anchored to photoreceptor membranes in retinal cells and deactivates G proteins in the rod and cone phototransduction cascades. Mutations in this gene result in bradyopsia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

Regulator Of G Protein Signaling 9

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to GNAT1. Involved in phototransduction; key element in the recovery phase of visual transduction (By similarity).

Biological Process dark adaptationIEA:Ensembl
Biological Process G protein-coupled receptor signaling pathwayTAS:Reactome
Biological Process intracellular signal transductionIEA:InterPro
Biological Process light adaptionIEA:Ensembl
Biological Process negative regulation of signal transductionIEA:UniProtKB-KW
Biological Process positive regulation of GTPase activityManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Biological Process visual perceptionIEA:UniProtKB-KW

Isoform 3
Membrane
Isoform 3 is targeted to the membrane via its interaction with RGS9BP.

Prolonged electroretinal response suppression (PERRS):
Characterized by difficulty adjusting to sudden changes in luminance levels mediated by cones.