Mouse Anti-RGS9 Recombinant Antibody (D7) (CBMAB-R2471-CN)

Name: Mouse Anti-RGS9 Recombinant Antibody (D7)
SKU: CBMAB-R2471-CN
Rating: 5 (1 reviews)

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Datasheet

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Basic Information

Host Animal

Mouse

Clone

Application

WB, IP, ICC, IHC-P

Specificity

Mouse, Cattle

Antibody Isotype

IgG1

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration

1.93 mg/mL

More Infomation

Target

Full Name

Regulator Of G Protein Signaling 9

Introduction

This gene encodes a member of the RGS family of GTPase activating proteins that function in various signaling pathways by accelerating the deactivation of G proteins. This protein is anchored to photoreceptor membranes in retinal cells and deactivates G proteins in the rod and cone phototransduction cascades. Mutations in this gene result in bradyopsia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

Entrez Gene ID

Cattle	281453
Mouse	19739

UniProt ID

Cattle	O46469
Mouse	O54828

Alternative Names

Regulator Of G Protein Signaling 9; Regulator Of G-Protein Signalling 9; Regulator Of G-Protein Signaling 9; Regulator Of G Protein Signalling 9L; Regulator Of G Protein Signalling 9; Regulator Of G-Protein Signaling 9L; PERRS; RGS9L;

Function

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to GNAT1. Involved in phototransduction; key element in the recovery phase of visual transduction (By similarity).

Biological Process

Biological Process dark adaptationIEA:Ensembl
Biological Process G protein-coupled receptor signaling pathwayTAS:Reactome
Biological Process intracellular signal transductionIEA:InterPro
Biological Process light adaptionIEA:Ensembl
Biological Process negative regulation of signal transductionIEA:UniProtKB-KW
Biological Process positive regulation of GTPase activityManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Biological Process visual perceptionIEA:UniProtKB-KW

Cellular Location

Isoform 3
Membrane
Isoform 3 is targeted to the membrane via its interaction with RGS9BP.

Involvement in disease

Prolonged electroretinal response suppression (PERRS):
Characterized by difficulty adjusting to sudden changes in luminance levels mediated by cones.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Mouse Anti-RGS9 Recombinant Antibody (D3) (CAT#: CBMAB-R2470-CN)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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