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Mouse Anti-RING1 Recombinant Antibody (2D5) (CBMAB-R2680-CN)

This product is a Mouse antibody that recognizes RING1. The antibody 2D5 can be used for immunoassay techniques such as: ELISA, ICC, IF, WB.
See all RING1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2D5
Antibody Isotype
IgG2b, κ
Application
ELISA, ICC, IF, WB

Basic Information

Immunogen
RING1 (NP_002922, aa. 81-170) partial recombinant protein with GST tag
Specificity
Human
Antibody Isotype
IgG2b, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Preservative
No preservatives
Concentration
0.2-1.0 mg/mL
Storage
Store at -20°C. Avoid Freeze/Thaw Cycles
Epitope
aa. 81-170

Target

Full Name
Ring Finger Protein 1
Introduction
This gene belongs to the RING finger family, members of which encode proteins characterized by a RING domain, a zinc-binding motif related to the zinc finger domain. The gene product can bind DNA and can act as a transcriptional repressor. It is associated with the multimeric polycomb group protein complex. The gene product interacts with the polycomb group proteins BMI1, EDR1, and CBX4, and colocalizes with these proteins in large nuclear domains. It interacts with the CBX4 protein via its glycine-rich C-terminal domain. The gene maps to the HLA class II region, where it is contiguous with the RING finger genes FABGL and HKE4. [provided by RefSeq, Jul 2008]
Entrez Gene ID
6015
UniProt ID
Q06587
Alternative Names
Ring Finger Protein 1; RING-Type E3 Ubiquitin Transferase RING1; Really Interesting New Gene 1 Protein; Polycomb Complex Protein RING1; RING Finger Protein 1; RNF1;
Function
Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase activity on histone H2A, and it may rather act as a modulator of RNF2/RING2 activity.
Biological Process
Biological Process anterior/posterior pattern specificationIEA:Ensembl
Biological Process camera-type eye morphogenesisIEA:Ensembl
Biological Process chromatin organizationIEA:UniProtKB-KW
Biological Process histone H2A monoubiquitinationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Nucleus
Nucleus speckle
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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