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Mouse Anti-RNF157 Recombinant Antibody (6B3) (CBMAB-R2956-CN)

This product is a Mouse antibody that recognizes RNF157. The antibody 6B3 can be used for immunoassay techniques such as: ELISA, WB.
See all RNF157 antibodies
Published Data
Fig. 1 MGRN1 interacts with cytosolic regions of GDU proteins and ubiquitylates cGDU1.
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Fig. 2 MGRN1 interacts with cytosolic regions of GDU proteins and ubiquitylates cGDU1.
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Fig. 3 RNF157 is predominantly expressed in the brain.
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Fig. 4 RNF157 is predominantly expressed in the brain.
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Fig. 5 RNF157 promotes neuronal survival.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
6B3
Antibody Isotype
IgG1, κ
Application
ELISA, WB

Basic Information

Immunogen
Partial recombinant corresponding to aa. 556-656 from human RNF157 (NP_443148) with GST tag
Specificity
Human
Antibody Isotype
IgG1, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2

Target

Full Name
Ring Finger Protein 157
Introduction
RNF157 (Ring Finger Protein 157) is a Protein Coding gene. An important paralog of this gene is MGRN1.
Entrez Gene ID
114804
UniProt ID
Q96PX1
Alternative Names
Ring Finger Protein 157; RING Finger Protein 157; RING-Type E3 Ubiquitin Transferase RNF157; EC 2.3.2.27; KIAA1917;
Function
E3 ubiquitin ligase that ubiquitinates APBB1 for its degradation by the proteasome and thus prevents apoptosis and promotes survival of neurons (PubMed:25342469).
Has a dual role in neurons as it is also required for dendrite growth and maintenance for which its ligase activity is not critical (PubMed:25342469).
May act as a scaffold molecule to regulate this process (PubMed:25342469).
Acts as a downstream effector of the interconnected PI3K and MAPK signaling pathways and thus participates in the regulation of the cell cycle (PubMed:28655764).
Biological Process
Biological Process endosome to lysosome transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of apoptotic processISS:UniProtKB
Biological Process negative regulation of cAMP-mediated signalingManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of dendrite extensionISS:UniProtKB
Biological Process protein autoubiquitinationISS:UniProtKB
Biological Process protein ubiquitinationISS:UniProtKB
Cellular Location
Cytoplasm
PTM
Phosphorylation at Ser-660, Ser-661, Ser-662 and Ser-663 downstream of the PI3K and MAPK pathways influences the E3 ligase activity and stability of RNF157 during the cell cycle in an anaphase-promoting complex/cyclosome-CDH1-dependent manner (PubMed:28655764).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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