RNF157

RNF157 (Ring Finger Protein 157) is a Protein Coding gene. An important paralog of this gene is MGRN1.

Full Name

Ring Finger Protein 157

Function

E3 ubiquitin ligase that ubiquitinates APBB1 for its degradation by the proteasome and thus prevents apoptosis and promotes survival of neurons (PubMed:25342469).
Has a dual role in neurons as it is also required for dendrite growth and maintenance for which its ligase activity is not critical (PubMed:25342469).
May act as a scaffold molecule to regulate this process (PubMed:25342469).
Acts as a downstream effector of the interconnected PI3K and MAPK signaling pathways and thus participates in the regulation of the cell cycle (PubMed:28655764).

Biological Process

Biological Process endosome to lysosome transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of apoptotic processISS:UniProtKB
Biological Process negative regulation of cAMP-mediated signalingManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of dendrite extensionISS:UniProtKB
Biological Process protein autoubiquitinationISS:UniProtKB
Biological Process protein ubiquitinationISS:UniProtKB

Cellular Location

Cytoplasm

PTM

Phosphorylation at Ser-660, Ser-661, Ser-662 and Ser-663 downstream of the PI3K and MAPK pathways influences the E3 ligase activity and stability of RNF157 during the cell cycle in an anaphase-promoting complex/cyclosome-CDH1-dependent manner (PubMed:28655764).