Mouse Anti-RNF157 Recombinant Antibody (CBCNR-589) (CBMAB-R2958-CN)

Name: Mouse Anti-RNF157 Recombinant Antibody (CBCNR-589)
SKU: CBMAB-R2958-CN
Rating: 5 (1 reviews)

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Datasheet

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Basic Information

Host Animal

Mouse

Clone

CBCNR-589

Application

Specificity

Human

Antibody Isotype

IgG1

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration

1 mg/mL

More Infomation

Target

Full Name

Ring Finger Protein 157

Introduction

RNF157 (Ring Finger Protein 157) is a Protein Coding gene. An important paralog of this gene is MGRN1.

Entrez Gene ID

114804

UniProt ID

Q96PX1

Alternative Names

Ring Finger Protein 157; RING Finger Protein 157; RING-Type E3 Ubiquitin Transferase RNF157; EC 2.3.2.27; KIAA1917;

Function

E3 ubiquitin ligase that ubiquitinates APBB1 for its degradation by the proteasome and thus prevents apoptosis and promotes survival of neurons (PubMed:25342469).
Has a dual role in neurons as it is also required for dendrite growth and maintenance for which its ligase activity is not critical (PubMed:25342469).
May act as a scaffold molecule to regulate this process (PubMed:25342469).
Acts as a downstream effector of the interconnected PI3K and MAPK signaling pathways and thus participates in the regulation of the cell cycle (PubMed:28655764).

Biological Process

Biological Process endosome to lysosome transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of apoptotic processISS:UniProtKB
Biological Process negative regulation of cAMP-mediated signalingManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of dendrite extensionISS:UniProtKB
Biological Process protein autoubiquitinationISS:UniProtKB
Biological Process protein ubiquitinationISS:UniProtKB

Cellular Location

Cytoplasm

PTM

Phosphorylation at Ser-660, Ser-661, Ser-662 and Ser-663 downstream of the PI3K and MAPK pathways influences the E3 ligase activity and stability of RNF157 during the cell cycle in an anaphase-promoting complex/cyclosome-CDH1-dependent manner (PubMed:28655764).

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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