Mouse Anti-SNUPN Recombinant Antibody (2B2-1B4) (CBMAB-A7689-LY)

Name: Mouse Anti-SNUPN Recombinant Antibody (2B2-1B4)
SKU: CBMAB-A7689-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

2B2-1B4

Application

WB, ELISA

Immunogen

RNUT1 (AAH04203, 1 a.a. ~ 360 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Specificity

Human

Antibody Isotype

IgG2a, κ

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Snurportin 1

Introduction

The nuclear import of the spliceosomal snRNPs U1, U2, U4 and U5, is dependent on the presence of a complex nuclear localization signal. The latter is composed of the 5'-2,2,7-terminal trimethylguanosine (m3G) cap structure of the U snRNA and the Sm core domain. The protein encoded by this gene interacts specifically with m3G-cap and functions as an snRNP-specific nuclear import receptor. Alternatively spliced transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq]

Entrez Gene ID

10073

UniProt ID

O95149

Alternative Names

KPNBL; RNUT1; Snurportin1

Function

Functions as an U snRNP-specific nuclear import adapter. Involved in the trimethylguanosine (m3G)-cap-dependent nuclear import of U snRNPs. Binds specifically to the terminal m3G-cap U snRNAs.

Biological Process

Biological Process protein import into nucleusIEA:InterPro
Biological Process RNA import into nucleusManual Assertion Based On ExperimentIDA:ComplexPortal
Biological Process snRNA import into nucleusIEA:InterPro

Cellular Location

Nucleus
Cytoplasm
Nucleoplasmic shuttling protein. Its nuclear import involves the nucleocytoplasmic transport receptor importin beta (PubMed:10209022, PubMed:12095920).
It is re-exported to the cytoplasm by the XPO1-dependent nuclear export receptor pathway (PubMed:10209022).

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Antibody Pairs

SNUPN Matched Antibody Pair (1116) (CAT#: APMAB-1116LY)

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SNUPN Matched Antibody Pair (1116) (CAT#: APMAB-1116LY)

Mouse Anti-SNUPN Recombinant Antibody (CBXS-2843) (CAT#: CBMAB-S5593-CQ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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