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Mouse Anti-RPN2 Recombinant Antibody (1G9) (CBMAB-R3427-CN)

This product is a Mouse antibody that recognizes RPN2. The antibody 1G9 can be used for immunoassay techniques such as: WB, IHC-P.
See all RPN2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1G9
Antibody Isotype
IgG1
Application
WB, IHC-P

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Target

Full Name
ribophorin II
Introduction
This gene encodes a type I integral membrane protein found only in the rough endoplasmic reticulum. The encoded protein is part of an N-oligosaccharyl transferase complex that links high mannose oligosaccharides to asparagine residues found in the Asn-X-Ser/Thr consensus motif of nascent polypeptide chains. This protein is similar in sequence to the yeast oligosaccharyl transferase subunit SWP1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
Entrez Gene ID
UniProt ID
Alternative Names
Ribophorin II; Dolichyl-Diphosphooligosaccharide--Protein Glycosyltransferase 63 KDa Subunit; Oligosaccharyltransferase Complex Subunit (Non-Catalytic); Ribophorin-2; RIBIIR; RPN-II;
Function
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc3Man9GlcNAc2 in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation (PubMed:31831667).
N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.
Biological Process
Biological Process agingIEA:Ensembl
Biological Process protein modification processManual Assertion Based On ExperimentTAS:ProtInc
Biological Process protein N-linked glycosylationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process protein N-linked glycosylation via asparagine1 PublicationNAS:HGNC-UCL
Biological Process response to xenobiotic stimulusIEA:Ensembl
Cellular Location
Endoplasmic reticulum
Endoplasmic reticulum membrane
Topology
Lumenal: 23-540
Helical: 541-561
Cytoplasmic: 562-571
Helical: 572-592
Lumenal: 593-596
Helical: 597-617
Cytoplasmic: 618-631
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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