Mouse Anti-RPS6KB2 Recombinant Antibody (164CT21.2.2) (CBMAB-R3585-CN)

Name: Mouse Anti-RPS6KB2 Recombinant Antibody (164CT21.2.2)
SKU: CBMAB-R3585-CN
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

164CT21.2.2

Application

Immunogen

RPS6KB2 recombinant protein

Specificity

Human, Mouse

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS

Preservative

0.09% Sodium azide

More Infomation

Target

Full Name

RPS6KB2

Introduction

This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains a kinase catalytic domain and phosphorylates the S6 ribosomal protein and eukaryotic translation initiation factor 4B (eIF4B). Phosphorylation of S6 leads to an increase in protein synthesis and cell proliferation. [provided by RefSeq, Jan 2015]

Entrez Gene ID

Human	6199
Mouse	58988

UniProt ID

Human	Q9UBS0
Mouse	Q9Z1M4

Alternative Names

Ribosomal Protein S6 Kinase B2; 70 KDa Ribosomal Protein S6 Kinase 2; Serine/Threonine-Protein Kinase 14B; P70 Ribosomal S6 Kinase Beta; S6 Kinase-Related Kinase; P70 S6 Kinase Beta; P70 S6K-Beta; EC 2.7.11.1; S6K-Beta-2; P70-S6K 2; P70 S6KB; P70-Beta; S6K-Beta; P70S6K2; STK14B;

Function

Phosphorylates specifically ribosomal protein S6 (PubMed:29750193).
Seems to act downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression in an alternative pathway regulated by MEAK7 (PubMed:29750193).

Biological Process

Biological Process peptidyl-serine phosphorylationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of translational initiationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process protein kinase B signalingIEA:Ensembl
Biological Process signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Biological Process TOR signalingManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process translationManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Cytoplasm
Nucleus

PTM

Phosphorylated and activated by MTOR. Phosphorylation by PKC within the NLS in response to mitogenic stimuli causes cytoplasmic retention.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Antibody Pairs

RPS6KB2 Matched Antibody Pair (1016) (CAT#: APMAB-1016LY)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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