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Mouse Anti-RPS6KB2 Recombinant Antibody (164CT21.2.2) (CBMAB-R3585-CN)

This product is a Mouse antibody that recognizes RPS6KB2. The antibody 164CT21.2.2 can be used for immunoassay techniques such as: WB.
See all RPS6KB2 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse
Clone
164CT21.2.2
Antibody Isotype
IgG1, κ
Application
WB

Basic Information

Immunogen
RPS6KB2 recombinant protein
Specificity
Human, Mouse
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS
Preservative
0.09% Sodium azide

Target

Full Name
RPS6KB2
Introduction
This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains a kinase catalytic domain and phosphorylates the S6 ribosomal protein and eukaryotic translation initiation factor 4B (eIF4B). Phosphorylation of S6 leads to an increase in protein synthesis and cell proliferation. [provided by RefSeq, Jan 2015]
Entrez Gene ID
Human6199
Mouse58988
UniProt ID
HumanQ9UBS0
MouseQ9Z1M4
Alternative Names
Ribosomal Protein S6 Kinase B2; 70 KDa Ribosomal Protein S6 Kinase 2; Serine/Threonine-Protein Kinase 14B; P70 Ribosomal S6 Kinase Beta; S6 Kinase-Related Kinase; P70 S6 Kinase Beta; P70 S6K-Beta; EC 2.7.11.1; S6K-Beta-2; P70-S6K 2; P70 S6KB; P70-Beta; S6K-Beta; P70S6K2; STK14B;
Function
Phosphorylates specifically ribosomal protein S6 (PubMed:29750193).
Seems to act downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression in an alternative pathway regulated by MEAK7 (PubMed:29750193).
Biological Process
Biological Process peptidyl-serine phosphorylationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of translational initiationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process protein kinase B signalingIEA:Ensembl
Biological Process signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Biological Process TOR signalingManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process translationManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Cytoplasm
Nucleus
PTM
Phosphorylated and activated by MTOR. Phosphorylation by PKC within the NLS in response to mitogenic stimuli causes cytoplasmic retention.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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