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RPS6KB2

This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates the S6 ribosomal protein and eucaryotic translation initiation factor 4B (eIF4B). Phosphorylation of S6 leads to an increase in protein synthesis and cell proliferation. [provided by RefSeq]

Full Name

RPS6KB2

Function

Phosphorylates specifically ribosomal protein S6 (PubMed:29750193).
Seems to act downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression in an alternative pathway regulated by MEAK7 (PubMed:29750193).

Biological Process

Biological Process peptidyl-serine phosphorylationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of translational initiationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process protein kinase B signalingIEA:Ensembl
Biological Process signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Biological Process TOR signalingManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process translationManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Cytoplasm
Nucleus

PTM

Phosphorylated and activated by MTOR. Phosphorylation by PKC within the NLS in response to mitogenic stimuli causes cytoplasmic retention.

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Anti-RPS6KB2 antibodies

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Mouse Anti-RPS6KB2 Recombinant Antibody (CBCNR-784) (CBMAB-R3590-CN)

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Target: RPS6KB2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Mouse, Rat, Human

Clone: CBCNR-784

Application*: WB

Mouse Anti-RPS6KB2 Recombinant Antibody (CBCNR-783) (CBMAB-R3589-CN)

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Target: RPS6KB2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Mouse, Rat, Human

Clone: CBCNR-783

Application*: WB

Mouse Anti-RPS6KB2 Recombinant Antibody (CBCNR-781) (CBMAB-R3587-CN)

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Target: RPS6KB2

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBCNR-781

Application*: IF, E, WB

Mouse Anti-RPS6KB2 Recombinant Antibody (4B11) (CBMAB-R3586-CN)

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Target: RPS6KB2

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 4B11

Application*: WB, E

Mouse Anti-RPS6KB2 Recombinant Antibody (164CT21.2.2) (CBMAB-R3585-CN)

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Target: RPS6KB2

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human, Mouse

Clone: 164CT21.2.2

Application*: WB

RPS6KB2 Matched Antibody Pair (1016) (APMAB-1016LY)

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Target: RPS6KB2

Specificity: Human

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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