Mouse Anti-RTKN Recombinant Antibody (1A4) (CBMAB-R3784-CN)

Name: Mouse Anti-RTKN Recombinant Antibody (1A4)
SKU: CBMAB-R3784-CN
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

1A4

Application

WB, IHC, IF

Immunogen

Full length human recombinant protein of human RTKN (NP_149035) produced in HEK293T cell

Specificity

Human

Antibody Isotype

IgG2a

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.3, 1% BSA, 50% Glycerol

Preservative

0.02% Sodium azide

Concentration

1 mg/mL

More Infomation

Target

Full Name

rhotekin

Introduction

This gene encodes a scaffold protein that interacts with GTP-bound Rho proteins. Binding of this protein inhibits the GTPase activity of Rho proteins. This protein may interfere with the conversion of active, GTP-bound Rho to the inactive GDP-bound form by RhoGAP. Rho proteins regulate many important cellular processes, including cytokinesis, transcription, smooth muscle contraction, cell growth and transformation. Dysregulation of the Rho signal transduction pathway has been implicated in many forms of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Entrez Gene ID

6242

UniProt ID

Q9BST9

Alternative Names

Rhotekin; RTKN1;

Function

Mediates Rho signaling to activate NF-kappa-B and may confer increased resistance to apoptosis to cells in gastric tumorigenesis. May play a novel role in the organization of septin structures.

Biological Process

Biological Process actomyosin contractile ring assemblyManual Assertion Based On ExperimentIBA:GO_Central
Biological Process apoptotic processIEA:UniProtKB-KW
Biological Process mitotic cytokinesisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of apoptotic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process Rho protein signal transductionManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process septin ring organizationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process signal transductionManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

actomyosin contractile ring
cytosol

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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