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Mouse Anti-RTKN Recombinant Antibody (CBCNR-844) (CBMAB-R3788-CN)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBCNR-844
Antibody Isotype
IgG1
Application
WB, IHC-P

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration
1 mg/mL

Target

Full Name
rhotekin
Introduction
This gene encodes a scaffold protein that interacts with GTP-bound Rho proteins. Binding of this protein inhibits the GTPase activity of Rho proteins. This protein may interfere with the conversion of active, GTP-bound Rho to the inactive GDP-bound form by RhoGAP. Rho proteins regulate many important cellular processes, including cytokinesis, transcription, smooth muscle contraction, cell growth and transformation. Dysregulation of the Rho signal transduction pathway has been implicated in many forms of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Entrez Gene ID
6242
UniProt ID
Q9BST9
Alternative Names
Rhotekin; RTKN1;
Function
Mediates Rho signaling to activate NF-kappa-B and may confer increased resistance to apoptosis to cells in gastric tumorigenesis. May play a novel role in the organization of septin structures.
Biological Process
Biological Process actomyosin contractile ring assemblyManual Assertion Based On ExperimentIBA:GO_Central
Biological Process apoptotic processIEA:UniProtKB-KW
Biological Process mitotic cytokinesisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of apoptotic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process Rho protein signal transductionManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process septin ring organizationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process signal transductionManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
actomyosin contractile ring
cytosol
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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