RTKN

This gene encodes a scaffold protein that interacts with GTP-bound Rho proteins. Binding of this protein inhibits the GTPase activity of Rho proteins. This protein may interfere with the conversion of active, GTP-bound Rho to the inactive GDP-bound form by RhoGAP. Rho proteins regulate many important cellular processes, including cytokinesis, transcription, smooth muscle contraction, cell growth and transformation. Dysregulation of the Rho signal transduction pathway has been implicated in many forms of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq]

rhotekin

Mediates Rho signaling to activate NF-kappa-B and may confer increased resistance to apoptosis to cells in gastric tumorigenesis. May play a novel role in the organization of septin structures.

Biological Process actomyosin contractile ring assemblyManual Assertion Based On ExperimentIBA:GO_Central
Biological Process apoptotic processIEA:UniProtKB-KW
Biological Process mitotic cytokinesisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of apoptotic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process Rho protein signal transductionManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process septin ring organizationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process signal transductionManual Assertion Based On ExperimentIDA:UniProtKB

actomyosin contractile ring
cytosol