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RTKN

This gene encodes a scaffold protein that interacts with GTP-bound Rho proteins. Binding of this protein inhibits the GTPase activity of Rho proteins. This protein may interfere with the conversion of active, GTP-bound Rho to the inactive GDP-bound form by RhoGAP. Rho proteins regulate many important cellular processes, including cytokinesis, transcription, smooth muscle contraction, cell growth and transformation. Dysregulation of the Rho signal transduction pathway has been implicated in many forms of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq]
Full Name
rhotekin
Function
Mediates Rho signaling to activate NF-kappa-B and may confer increased resistance to apoptosis to cells in gastric tumorigenesis. May play a novel role in the organization of septin structures.
Biological Process
Biological Process actomyosin contractile ring assemblyManual Assertion Based On ExperimentIBA:GO_Central
Biological Process apoptotic processIEA:UniProtKB-KW
Biological Process mitotic cytokinesisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of apoptotic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process Rho protein signal transductionManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process septin ring organizationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process signal transductionManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
actomyosin contractile ring
cytosol
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Anti-RTKN antibodies

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Mouse Anti-RTKN Recombinant Antibody (CBCNR-844) (CBMAB-R3788-CN)

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Target: RTKN
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBCNR-844
Application*: WB, P
Datasheet SDS

Mouse Anti-RTKN Recombinant Antibody (CBCNR-843) (CBMAB-R3787-CN)

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Target: RTKN
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBCNR-843
Application*: E, WB, P
Datasheet SDS

Mouse Anti-RTKN Recombinant Antibody (2E9) (CBMAB-R3786-CN)

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Target: RTKN
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 2E9
Application*: WB, IH
Datasheet SDS

Mouse Anti-RTKN Recombinant Antibody (2E5) (CBMAB-R3785-CN)

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Target: RTKN
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 2E5
Application*: E, IH, WB
Datasheet SDS

Mouse Anti-RTKN Recombinant Antibody (1A4) (CBMAB-R3784-CN)

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Target: RTKN
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 1A4
Application*: WB, IH, IF
Datasheet SDS
More Infomation
Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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