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Mouse Anti-S1PR5 Recombinant Antibody (CBXS-1749) (CBMAB-S0107-CQ)

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Datasheet
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Basic Information

Host Animal
Mouse
Clone
CBXS-1749
Application
FC
Immunogen
BaF3 mouse pro-B cell line transfected with human S1P5/EDG-8, Met1-Asp398, Accession # Q9H228
Specificity
Human, Mouse
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
A saline solution, BSA
Preservative
Sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
More Infomation

Target

Full Name
Sphingosine-1-Phosphate Receptor 5
Introduction
The lysosphingolipid sphingosine 1-phosphate (S1P) regulates cell proliferation, apoptosis, motility, and neurite retraction. Its actions may be both intracellular as a second messenger and extracellular as a receptor ligand. S1P and the structurally related lysolipid mediator lysophosphatidic acid (LPA) signal cells through a set of G protein-coupled receptors known as EDG receptors. Some EDG receptors (e.g., EDG1; MIM 601974) are S1P receptors; others (e.g., EDG2; MIM 602282) are LPA receptors.
Entrez Gene ID
Human53637
Mouse94226
UniProt ID
HumanQ9H228
MouseQ91X56
Alternative Names
Sphingosine-1-Phosphate Receptor 5; Endothelial Differentiation, Sphingolipid G-Protein-Coupled Receptor, 8; Endothelial Differentiation G-Protein-Coupled Receptor 8; Sphingosine 1-Phosphate Receptor Edg-8; S1P Receptor Edg-8; S1P Receptor 5; EDG8;
Function
Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. Is coupled to both the G(i/0)alpha and G12 subclass of heteromeric G-proteins (By similarity).
May play a regulatory role in the transformation of radial glial cells into astrocytes and may affect proliferative activity of these cells.
Biological Process
Biological Process adenylate cyclase-activating G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of metabolic processManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of neuron differentiationIEA:Ensembl
Cellular Location
Cell membrane
Topology
Extracellular: 1-40
Helical: 41-61
Cytoplasmic: 62-70
Helical: 71-91
Extracellular: 92-111
Helical: 112-132
Cytoplasmic: 133-151
Helical: 152-172
Extracellular: 173-192
Helical: 193-213
Cytoplasmic: 214-252
Helical: 253-273
Extracellular: 274-287
Helical: 288-308
Cytoplasmic: 309-398
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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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