S1PR5

The lysosphingolipid sphingosine 1-phosphate (S1P) regulates cell proliferation, apoptosis, motility, and neurite retraction. Its actions may be both intracellular as a second messenger and extracellular as a receptor ligand. S1P and the structurally related lysolipid mediator lysophosphatidic acid (LPA) signal cells through a set of G protein-coupled receptors known as EDG receptors. Some EDG receptors (e.g., EDG1; MIM 601974) are S1P receptors; others (e.g., EDG2; MIM 602282) are LPA receptors.[supplied by OMIM, Mar 2008]

Full Name

Sphingosine-1-Phosphate Receptor 5

Function

Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. Is coupled to both the G(i/0)alpha and G12 subclass of heteromeric G-proteins (By similarity).
May play a regulatory role in the transformation of radial glial cells into astrocytes and may affect proliferative activity of these cells.

Biological Process

Biological Process adenylate cyclase-activating G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of metabolic processManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of neuron differentiationIEA:Ensembl

Cellular Location

Cell membrane

Topology

Extracellular: 1-40
Helical: 41-61
Cytoplasmic: 62-70
Helical: 71-91
Extracellular: 92-111
Helical: 112-132
Cytoplasmic: 133-151
Helical: 152-172
Extracellular: 173-192
Helical: 193-213
Cytoplasmic: 214-252
Helical: 253-273
Extracellular: 274-287
Helical: 288-308
Cytoplasmic: 309-398