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Mouse Anti-SAMD4A Recombinant Antibody (1A4) (CBMAB-A7887-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
1A4
Antibody Isotype
IgG2b, κ
Application
WB, ELISA

Basic Information

Immunogen
SAMD4A (NP_056404.2, 161 a.a. ~ 270 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
sterile alpha motif domain containing 4A
Introduction
Sterile alpha motifs (SAMs) in proteins such as SAMD4A are part of an RNA-binding domain that functions as a posttranscriptional regulator by binding to an RNA sequence motif known as the Smaug recognition element, which was named after the Drosophila Smaug protein (Baez and Boccaccio, 2005 [PubMed 16221671]).[supplied by OMIM
Entrez Gene ID
23034
UniProt ID
Q9UPU9
Alternative Names
DKFZp434H0350; KIAA1053; SAMD4; SMG; SMGA; Smaug; Smaug1
Function
Acts as a translational repressor of SRE-containing messengers.
Biological Process
Biological Process nuclear-transcribed mRNA poly(A) tail shorteningManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of translationManual Assertion Based On ExperimentIDA:MGI
Cellular Location
Cytoplasm
Cell projection, dendrite
Synapse, synaptosome
Enriched in synaptoneurosomes (By similarity).
Shuttles between the nucleus and the cytoplasm in a CRM1-dependent manner. Colocalizes throughout the cytoplasm in granules with polyadenylated RNAs, PABPC1 and STAU1. Also frequently colocalizes in cytoplasmic stress granule-like foci with ELAVL1, TIA1 and TIAL1.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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