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Mouse Anti-SAMD4A Recombinant Antibody (CBXS-2672) (CBMAB-S5424-CQ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-2672
Antibody Isotype
IgG2b, κ
Application
ELISA, WB

Basic Information

Immunogen
Partial recombinant corresponding to aa161-270 from SAMD4A (NP_056404) with GST tag
Specificity
Human
Antibody Isotype
IgG2b, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
sterile alpha motif domain containing 4A
Introduction
Sterile alpha motifs (SAMs) in proteins such as SAMD4A are part of an RNA-binding domain that functions as a posttranscriptional regulator by binding to an RNA sequence motif known as the Smaug recognition element, which was named after the Drosophila Smaug protein (Baez and Boccaccio, 2005 [PubMed 16221671]).
Entrez Gene ID
23034
UniProt ID
Q9UPU9
Alternative Names
Sterile Alpha Motif Domain Containing 4A; SAM Domain-Containing Protein 4A; SMAUG1; SAMD4; Sterile Alpha Motif Domain-Containing Protein 4A; Sterile Alpha Motif Domain Containing 4; Smaug Homolog (Drosophila); Protein Smaug Homolog 1;
Function
Acts as a translational repressor of SRE-containing messengers.
Biological Process
Biological Process nuclear-transcribed mRNA poly(A) tail shorteningManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of translationManual Assertion Based On ExperimentIDA:MGI
Cellular Location
Cytoplasm
Cell projection, dendrite
Synapse, synaptosome
Enriched in synaptoneurosomes (By similarity).
Shuttles between the nucleus and the cytoplasm in a CRM1-dependent manner. Colocalizes throughout the cytoplasm in granules with polyadenylated RNAs, PABPC1 and STAU1. Also frequently colocalizes in cytoplasmic stress granule-like foci with ELAVL1, TIA1 and TIAL1.
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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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