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SAMD4A

Sterile alpha motifs (SAMs) in proteins such as SAMD4A are part of an RNA-binding domain that functions as a posttranscriptional regulator by binding to an RNA sequence motif known as the Smaug recognition element, which was named after the Drosophila Smaug protein (Baez and Boccaccio, 2005 [PubMed 16221671]).[supplied by OMIM

Full Name

sterile alpha motif domain containing 4A

Function

Acts as a translational repressor of SRE-containing messengers.

Biological Process

Biological Process nuclear-transcribed mRNA poly(A) tail shorteningManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of translationManual Assertion Based On ExperimentIDA:MGI

Cellular Location

Cytoplasm
Cell projection, dendrite
Synapse, synaptosome
Enriched in synaptoneurosomes (By similarity).
Shuttles between the nucleus and the cytoplasm in a CRM1-dependent manner. Colocalizes throughout the cytoplasm in granules with polyadenylated RNAs, PABPC1 and STAU1. Also frequently colocalizes in cytoplasmic stress granule-like foci with ELAVL1, TIA1 and TIAL1.

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Anti-SAMD4A antibodies

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Mouse Anti-SAMD4A Recombinant Antibody (1A4) (CBMAB-A7887-LY)

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Target: SAMD4A

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: 1A4

Application*: WB, E

Mouse Anti-SAMD4A Recombinant Antibody (CBXS-2672) (CBMAB-S5424-CQ)

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Target: SAMD4A

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: CBXS-2672

Application*: E, WB

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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