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Mouse Anti-SCARB2 Recombinant Antibody (1C8) (CBMAB-A7909-LY)

The product is antibody recognizes SCARB2. The antibody 1C8 immunoassay techniques such as: sELISA, ELISA.
See all SCARB2 antibodies
Published Data
Fig. 1 Cell surface expression of SCARB2 in six cells. Three parental cells were stained with an anti-SCARB2 antibody (solid lines), SCARB2 cells were stained with an anti-SCARB2 antibody (grey region) or a secondary antibody alone (dotted lines) and analyzed by flow cytometry.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
1C8
Antibody Isotype
IgG2a, κ
Application
sELISA, ELISA

Basic Information

Immunogen
SCARB2 (NP_005497, 339 a.a. ~ 437 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
scavenger receptor class B, member 2
Introduction
The protein encoded by this gene is a type III glycoprotein that is located primarily in limiting membranes of lysosomes and endosomes. Studies of the similar protein in mice and rat suggested that this protein may participate in membrane transportation and the reorganization of endosomal/lysosomal compartment. Deficiency of the similar protein in mice was reported to impair cell membrane transport processes and cause pelvic junction obstruction, deafness, and peripheral neuropathy. [provided by RefSeq]
Entrez Gene ID
950
UniProt ID
Q14108
Alternative Names
AMRF; CD36L2; HLGP85; LIMPII; SR-BII
Function
Acts as a lysosomal receptor for glucosylceramidase (GBA1) targeting.
(Microbial infection) Acts as a receptor for enterovirus 71.
Biological Process
Biological Process aminophospholipid transportBy SimilarityISS:ARUK-UCL
Biological Process gene expressionIEA:Ensembl
Biological Process positive regulation of neuron projection developmentISS:ARUK-UCL
Biological Process protein targeting to lysosomeManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process receptor-mediated endocytosisBy SimilarityISS:ARUK-UCL
Biological Process regulation of cellular carbohydrate catabolic processManual Assertion Based On ExperimentIMP:ARUK-UCL
Biological Process regulation of endosome organizationManual Assertion Based On ExperimentTAS:ParkinsonsUK-UCL
Biological Process regulation of glucosylceramidase activityManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of lysosome organizationManual Assertion Based On ExperimentTAS:ParkinsonsUK-UCL
Biological Process sensory perception of soundIEA:Ensembl
Cellular Location
Lysosome membrane
Involvement in disease
Epilepsy, progressive myoclonic 4, with or without renal failure (EPM4):
A form of progressive myoclonic epilepsy, a clinically and genetically heterogeneous group of disorders defined by the combination of action and reflex myoclonus, other types of epileptic seizures, and progressive neurodegeneration and neurocognitive impairment. EPM4 is an autosomal recessive form associated with renal failure in some cases. Cognitive function is preserved.
Topology
Cytoplasmic: 1-4
Helical: 5-27
Lumenal: 28-433
Helical: 434-459
Cytoplasmic: 460-478
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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