Mouse Anti-SCARB2 Recombinant Antibody (CBYJL-168) (CBMAB-L0245-YJ)

Name: Mouse Anti-SCARB2 Recombinant Antibody (CBYJL-168)
SKU: CBMAB-L0245-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBYJL-168

Application

ELISA

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.4

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

scavenger receptor class B, member 2

Introduction

SCARB2 is a type III glycoprotein that is located mainly in limiting membranes of lysosomes and endosomes. Earlier studies in mice and rat suggested that SCARB2 may participate in membrane transportation and the reorganization of endosomal/lysosomal compartment. The protein deficiency in mice was proved to impair cell membrane transport processes and cause pelvic junction obstruction, deafness, and peripheral neuropathy. Further studies in human showed that SCARB2 is a ubiquitously expressed protein and that it is involved in the pathogenesis of HFMD (hand, foot, and mouth disease) caused by enterovirus-71 and possibly by coxsackievirus A16. Mutations in this gene occasioned an autosomal recessive progressive myoclonic epilepsy-4 (EPM4), also known as action myoclonus-renal failure syndrome (AMRF). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Entrez Gene ID

950

UniProt ID

Q14108

Alternative Names

Scavenger Receptor Class B Member 2; CD36 Antigen (Collagen Type I Receptor; Thrombospondin Receptor)-Like 2 (Lysosomal Integral Membrane Protein II); 85 KDa Lysosomal Membrane Sialoglycoprotein; Lysosome Membrane Protein II; CD36 Antigen-Like 2; LIMP II; CD36L2; LIMPII; LGP85; 85 KDa Lysosomal Sialoglycoprotein Scavenger Receptor Class B; Member 2

Function

Acts as a lysosomal receptor for glucosylceramidase (GBA1) targeting.
(Microbial infection) Acts as a receptor for enterovirus 71.

Biological Process

Biological Process aminophospholipid transportBy SimilarityISS:ARUK-UCL
Biological Process gene expressionIEA:Ensembl
Biological Process positive regulation of neuron projection developmentISS:ARUK-UCL
Biological Process protein targeting to lysosomeManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process receptor-mediated endocytosisBy SimilarityISS:ARUK-UCL
Biological Process regulation of cellular carbohydrate catabolic processManual Assertion Based On ExperimentIMP:ARUK-UCL
Biological Process regulation of endosome organizationManual Assertion Based On ExperimentTAS:ParkinsonsUK-UCL
Biological Process regulation of glucosylceramidase activityManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of lysosome organizationManual Assertion Based On ExperimentTAS:ParkinsonsUK-UCL
Biological Process sensory perception of soundIEA:Ensembl

Cellular Location

Lysosome membrane

Involvement in disease

Epilepsy, progressive myoclonic 4, with or without renal failure (EPM4):
A form of progressive myoclonic epilepsy, a clinically and genetically heterogeneous group of disorders defined by the combination of action and reflex myoclonus, other types of epileptic seizures, and progressive neurodegeneration and neurocognitive impairment. EPM4 is an autosomal recessive form associated with renal failure in some cases. Cognitive function is preserved.

Topology

Cytoplasmic: 1-4
Helical: 5-27
Lumenal: 28-433
Helical: 434-459
Cytoplasmic: 460-478

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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