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Rabbit Anti-SCARB2 Recombinant Antibody (CBXS-1304) (CBMAB-S4163-CQ)

This product is a rabbit antibody that recognizes SCARB2. The antibody CBXS-1304 can be used for immunoassay techniques such as: WB, IHC-P, FC.
See all SCARB2 antibodies

Summary

Host Animal
Rabbit
Specificity
Mouse, Rat, Human
Clone
CBXS-1304
Antibody Isotype
IgG
Application
WB, IHC-P, FC

Basic Information

Specificity
Mouse, Rat, Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration
0.783 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
scavenger receptor class B, member 2
Introduction
The protein encoded by this gene is a type III glycoprotein that is located primarily in limiting membranes of lysosomes and endosomes. Earlier studies in mice and rat suggested that this protein may participate in membrane transportation and the reorganization of endosomal/lysosomal compartment. The protein deficiency in mice was reported to impair cell membrane transport processes and cause pelvic junction obstruction, deafness, and peripheral neuropathy. Further studies in human showed that this protein is a ubiquitously expressed protein and that it is involved in the pathogenesis of HFMD (hand, foot, and mouth disease) caused by enterovirus-71 and possibly by coxsackievirus A16. Mutations in this gene caused an autosomal recessive progressive myoclonic epilepsy-4 (EPM4), also known as action myoclonus-renal failure syndrome (AMRF). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Entrez Gene ID
Human950
Mouse12492
Rat117106
UniProt ID
HumanQ14108
MouseO35114
RatP27615
Alternative Names
Scavenger Receptor Class B Member 2; CD36 Antigen (Collagen Type I Receptor, Thrombospondin Receptor)-Like 2 (Lysosomal Integral Membrane Protein II); 85 KDa Lysosomal Membrane Sialoglycoprotein; Lysosome Membrane Protein II; CD36 Antigen-Like 2; LIMP II; CD36L2; LIMPII; LGP85; 85 KDa Lysosomal Sialoglycoprotein Scavenger Receptor Class B, Member 2;
Function
Acts as a lysosomal receptor for glucosylceramidase (GBA1) targeting.
(Microbial infection) Acts as a receptor for enterovirus 71.
Biological Process
Biological Process aminophospholipid transportBy SimilarityISS:ARUK-UCL
Biological Process gene expressionIEA:Ensembl
Biological Process positive regulation of neuron projection developmentISS:ARUK-UCL
Biological Process protein targeting to lysosomeManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process receptor-mediated endocytosisBy SimilarityISS:ARUK-UCL
Biological Process regulation of cellular carbohydrate catabolic processManual Assertion Based On ExperimentIMP:ARUK-UCL
Biological Process regulation of endosome organizationManual Assertion Based On ExperimentTAS:ParkinsonsUK-UCL
Biological Process regulation of glucosylceramidase activityManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of lysosome organizationManual Assertion Based On ExperimentTAS:ParkinsonsUK-UCL
Biological Process sensory perception of soundIEA:Ensembl
Cellular Location
Lysosome membrane
Involvement in disease
Epilepsy, progressive myoclonic 4, with or without renal failure (EPM4):
A form of progressive myoclonic epilepsy, a clinically and genetically heterogeneous group of disorders defined by the combination of action and reflex myoclonus, other types of epileptic seizures, and progressive neurodegeneration and neurocognitive impairment. EPM4 is an autosomal recessive form associated with renal failure in some cases. Cognitive function is preserved.
Topology
Cytoplasmic: 1-4
Helical: 5-27
Lumenal: 28-433
Helical: 434-459
Cytoplasmic: 460-478
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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