SCARB2

The protein encoded by this gene is a type III glycoprotein that is located primarily in limiting membranes of lysosomes and endosomes. Studies of the similar protein in mice and rat suggested that this protein may participate in membrane transportation and the reorganization of endosomal/lysosomal compartment. Deficiency of the similar protein in mice was reported to impair cell membrane transport processes and cause pelvic junction obstruction, deafness, and peripheral neuropathy. [provided by RefSeq]

scavenger receptor class B, member 2

Acts as a lysosomal receptor for glucosylceramidase (GBA1) targeting.
(Microbial infection) Acts as a receptor for enterovirus 71.

Biological Process aminophospholipid transportBy SimilarityISS:ARUK-UCL
Biological Process gene expressionIEA:Ensembl
Biological Process positive regulation of neuron projection developmentISS:ARUK-UCL
Biological Process protein targeting to lysosomeManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process receptor-mediated endocytosisBy SimilarityISS:ARUK-UCL
Biological Process regulation of cellular carbohydrate catabolic processManual Assertion Based On ExperimentIMP:ARUK-UCL
Biological Process regulation of endosome organizationManual Assertion Based On ExperimentTAS:ParkinsonsUK-UCL
Biological Process regulation of glucosylceramidase activityManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of lysosome organizationManual Assertion Based On ExperimentTAS:ParkinsonsUK-UCL
Biological Process sensory perception of soundIEA:Ensembl

Lysosome membrane

Epilepsy, progressive myoclonic 4, with or without renal failure (EPM4):
A form of progressive myoclonic epilepsy, a clinically and genetically heterogeneous group of disorders defined by the combination of action and reflex myoclonus, other types of epileptic seizures, and progressive neurodegeneration and neurocognitive impairment. EPM4 is an autosomal recessive form associated with renal failure in some cases. Cognitive function is preserved.

Cytoplasmic: 1-4
Helical: 5-27
Lumenal: 28-433
Helical: 434-459
Cytoplasmic: 460-478