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Rabbit Anti-SCD Recombinant Antibody (C12H5) (CBMAB-CP2361-LY)


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Summary

Host Animal
Rabbit
Specificity
Human, Mouse
Clone
C12H5
Antibody Isotype
IgG
Application
WB, IP, IHC-P, IF (ICC)

Basic Information

Immunogen
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu35 of mouse SCD1.
Specificity
Human, Mouse
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Stearoyl-CoA Desaturase
Introduction
This gene encodes an enzyme involved in fatty acid biosynthesis, primarily the synthesis of oleic acid. The protein belongs to the fatty acid desaturase family and is an integral membrane protein located in the endoplasmic reticulum. Transcripts of approximately 3.9 and 5.2 kb, differing only by alternative polyadenlyation signals, have been detected. A gene encoding a similar enzyme is located on chromosome 4 and a pseudogene of this gene is located on chromosome 17. [provided by RefSeq, Sep 2015]
Entrez Gene ID
6319
UniProt ID
O00767
Alternative Names
Stearoyl-CoA Desaturase; Fatty Acid Desaturase; Stearoyl-CoA Desaturase (Delta-9-Desaturase); Stearoyl-CoA Desaturase Opposite Strand; Acyl-CoA Desaturase; Delta(9)-Desaturase; EC 1.14.19.1; HSCD1;
Function
Stearoyl-CoA desaturase that utilizes O2 and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates (PubMed:15907797, PubMed:18765284).
Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA (PubMed:15907797, PubMed:18765284).
Gives rise to a mixture of 16:1 and 18:1 unsaturated fatty acids (PubMed:15610069).
Plays an important role in lipid biosynthesis. Plays an important role in regulating the expression of genes that are involved in lipogenesis and in regulating mitochondrial fatty acid oxidation (By similarity).
Plays an important role in body energy homeostasis (By similarity).
Contributes to the biosynthesis of membrane phospholipids, cholesterol esters and triglycerides (By similarity).
Biological Process
Biological Process monounsaturated fatty acid biosynthetic processManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of cold-induced thermogenesisBy SimilarityISS:YuBioLab
Biological Process response to fatty acidManual Assertion Based On ExperimentIBA:GO_Central
Biological Process unsaturated fatty acid biosynthetic processManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Endoplasmic reticulum membrane
Topology
Cytoplasmic: 1-72
Helical: 73-93
Lumenal: 94-97
Helical: 98-118
Cytoplasmic: 119-217
Helical: 218-237
Lumenal: 238-241
Helical: 242-263
Cytoplasmic: 264-359
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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