Rabbit Anti-SCD Recombinant Antibody (C12H5) (CBMAB-CP2361-LY)

Name: Rabbit Anti-SCD Recombinant Antibody (C12H5)
SKU: CBMAB-CP2361-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Rabbit

Clone

C12H5

Application

WB, IP, IHC-P, IF (ICC)

Immunogen

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu35 of mouse SCD1.

Specificity

Human, Mouse

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

100 µg/ml BSA, 50% glycerol

Preservative

0.02% sodium azide

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Stearoyl-CoA Desaturase

Introduction

This gene encodes an enzyme involved in fatty acid biosynthesis, primarily the synthesis of oleic acid. The protein belongs to the fatty acid desaturase family and is an integral membrane protein located in the endoplasmic reticulum. Transcripts of approximately 3.9 and 5.2 kb, differing only by alternative polyadenlyation signals, have been detected. A gene encoding a similar enzyme is located on chromosome 4 and a pseudogene of this gene is located on chromosome 17. [provided by RefSeq, Sep 2015]

Entrez Gene ID

6319

UniProt ID

O00767

Alternative Names

Stearoyl-CoA Desaturase; Fatty Acid Desaturase; Stearoyl-CoA Desaturase (Delta-9-Desaturase); Stearoyl-CoA Desaturase Opposite Strand; Acyl-CoA Desaturase; Delta(9)-Desaturase; EC 1.14.19.1; HSCD1;

Function

Stearoyl-CoA desaturase that utilizes O2 and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates (PubMed:15907797, PubMed:18765284).
Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA (PubMed:15907797, PubMed:18765284).
Gives rise to a mixture of 16:1 and 18:1 unsaturated fatty acids (PubMed:15610069).
Plays an important role in lipid biosynthesis. Plays an important role in regulating the expression of genes that are involved in lipogenesis and in regulating mitochondrial fatty acid oxidation (By similarity).
Plays an important role in body energy homeostasis (By similarity).
Contributes to the biosynthesis of membrane phospholipids, cholesterol esters and triglycerides (By similarity).

Biological Process

Biological Process monounsaturated fatty acid biosynthetic processManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of cold-induced thermogenesisBy SimilarityISS:YuBioLab
Biological Process response to fatty acidManual Assertion Based On ExperimentIBA:GO_Central
Biological Process unsaturated fatty acid biosynthetic processManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Endoplasmic reticulum membrane

Topology

Cytoplasmic: 1-72
Helical: 73-93
Lumenal: 94-97
Helical: 98-118
Cytoplasmic: 119-217
Helical: 218-237
Lumenal: 238-241
Helical: 242-263
Cytoplasmic: 264-359

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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